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    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Misic, a general deep learning-based method for the high-throughput cell segmentation of complex bacterial communities

    Swapnesh Panigrahi, Dorothée Murat ... Tâm Mignot
    A broadly applicable deep-learning based method that recognizes rod-shaped bacteria of virtually any species in complex bacterial communities.
    1. Neuroscience

    Robust cone-mediated signaling persists late into rod photoreceptor degeneration

    Miranda L Scalabrino, Mishek Thapa ... Greg D Field
    The retina compensates for rod death and deteriorating cones to retain high-fidelity visual signaling to the brain.
    1. Cell Biology
    2. Neuroscience

    Glycolytic reliance promotes anabolism in photoreceptors

    Yashodhan Chinchore, Tedi Begaj ... Constance L Cepko
    Aerobic glycolysis in rod photoreceptors of adult mice is regulated by allostery and FGF signaling and is required for maintaining outer segments.
    1. Plant Biology
    2. Structural Biology and Molecular Biophysics

    In situ cryo-ET structure of phycobilisome–photosystem II supercomplex from red alga

    Meijing Li, Jianfei Ma ... Sen-Fang Sui
    The nature of the phycobilisome–photosystem II supercomplex on the native thylakoid determined with cryo-electron tomography at an unprecedented resolution reveals that one phycobilisome interconnects with six photosystem monomers.
    1. Neuroscience

    A dual role for Cav1.4 Ca2+ channels in the molecular and structural organization of the rod photoreceptor synapse

    J Wesley Maddox, Kate L Randall ... Amy Lee
    Ca2+ influx through Cav1.4 channels is required for the structural, but not the molecular organization of the rod photoreceptor synapse.
    1. Neuroscience

    Mouse rods signal through gap junctions with cones

    Sabrina Asteriti, Claudia Gargini, Lorenzo Cangiano
    Electrophysiological recordings show that cones in the eyes of mice are able to receive strong input from rods via gap junctions, supporting the view that this route plays an important role in vision.
    1. Neuroscience

    Cross-synaptic synchrony and transmission of signal and noise across the mouse retina

    William N Grimes, Mrinalini Hoon ... Fred Rieke
    Cells within the retina synchronize transmitter release across their output synapses in the dark, reducing the impact of noise generated at these synapses and allowing light-dependent signals to be transmitted with minimal added synaptic noise.
    1. Developmental Biology
    2. Neuroscience

    Retinoic acid signaling mediates peripheral cone photoreceptor survival in a mouse model of retina degeneration

    Ryoji Amamoto, Grace K Wallick, Constance L Cepko
    Retinoic acid signaling from Muller glia is necessary for cone photoreceptor survival in the peripheral retina and is sufficient to promote cone survival in the central retina during retinal degeneration.
    1. Structural Biology and Molecular Biophysics

    Structure of mouse protocadherin 15 of the stereocilia tip link in complex with LHFPL5

    Jingpeng Ge, Johannes Elferich ... Eric Gouaux
    Structures of a mouse PCDH15 and LHFPL5 complex, two proteins involved in converting sound into electrical signals, illuminate how mechanical stimuli are delivered to the membrane of inner ear hair cells.
    1. Microbiology and Infectious Disease

    Distinct regions of H. pylori’s bactofilin CcmA regulate protein–protein interactions to control helical cell shape

    Sophie R Sichel, Benjamin P Bratton, Nina R Salama
    The helical cell shape of Helicobacter pylori depends on the polymerizing cytoskeletal protein CcmA’s recruitment to the cell envelope by Csd5 and CcmA’s indirect stabilization of a periplasmic cell wall hydrolase via interactions with the transmembrane protein Csd7.