An alternative method for mapping RNA polymerase II occupancy over the genome provides new insights into the kinetics and molecular mechanism of transcription.

A novel pair of isobaric crosslinking reagents is described, which allow relative quantification of crosslinker-modified peptides during mass spectrometry analysis for comparative structural studies of proteins and protein complexes.

In response to ethanol stress, the yeast transcription factor Hsf1 forms nuclear condensates and drives the coalescence of target genes prior to their transcriptional activation while in response to thermal stress these three phenomena are tightly coordinated.

Class-specific transcription factor links transcription backtracking with cytoplasmic mRNA decay via co-transcriptional interaction with nascent transcripts.

High-resolution mapping of RNA polymerase II transcripts shows that the directionality of mammalian promoters is determined by preferential transcriptional initiation and the opposing activities of Integrator and CDK9.

The yeast mRNA decapping enzyme Dcp1/Dcp2 repressses many genes whose products are required on poor carbon or nitrogen sources in nutrient-replete cells by mRNA decapping and degradation or translational repression, adding post-transcriptional controls to the transcriptional repression of these functions.

The propensity to endogenize and domesticate dsDNA viruses depends on lifestyle in Hymenoptera.

Secondary metabolites rocaglates produced by plants lead to a plant‒fungus tug-of-war, utilizing unique amino acid substitutions in eIF4A, a target of the compounds.