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    1. Biochemistry and Chemical Biology

    Translation attenuation by minocycline enhances longevity and proteostasis in old post-stress-responsive organisms

    Gregory M Solis et al.
    Directly targeting the ribosome to attenuate translation partly mimics the integrated stress response, increasing lifespan and preserving protein folding capacity even in older individuals with dysfunctional stress response signaling.
    1. Cell Biology

    The yeast H+-ATPase Pma1 promotes Rag/Gtr-dependent TORC1 activation in response to H+-coupled nutrient uptake

    Elie Saliba et al.
    The H+ influx coupled to nutrient uptake and the plasma membrane H+-ATPase are central actors of the activation of target of rapamycin complex 1 (TORC1) in budding yeast Saccharomyces cerevisiae..
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Discovery of a small molecule that inhibits bacterial ribosome biogenesis

    Jonathan M Stokes et al.
    The anticonvulsant drug lamotrigine inhibits bacterial ribosome biogenesis and reveals an unexplored role for initiation factor 2 (IF2) in ribosome assembly.
    1. Cell Biology

    Meiotic cellular rejuvenation is coupled to nuclear remodeling in budding yeast

    Grant A King et al.
    A meiotic nuclear remodeling event mediates cellular rejuvenation through elimination of senescence factors.
    1. Neuroscience

    Axon TRAP reveals learning-associated alterations in cortical axonal mRNAs in the lateral amgydala

    Linnaea E Ostroff et al.
    A diverse assortment of mRNAs are present in projection axons in the adult forebrain and their translation is associated with new memory formation.
    1. Cell Biology
    2. Developmental Biology

    Recruitment of mRNAs to P granules by condensation with intrinsically-disordered proteins

    Chih-Yung S Lee et al.
    The intrinsically-disordered protein MEG-3 recruits mRNAs to P granules by forming gel-like condensates with ribosome-depleted mRNAs.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Evidence for DNA-mediated nuclear compartmentalization distinct from phase separation

    David Trombley McSwiggen et al.
    Transient DNA interactions by DNA-binding proteins are utilized by herpes simple virus as an alternative route to generate membraneless compartments in the nucleus without invoking phase separation.
    1. Chromosomes and Gene Expression

    Exploration of CTCF post-translation modifications uncovers Serine-224 phosphorylation by PLK1 at pericentric regions during the G2/M transition

    Brian C Del Rosario et al.
    The chromosome architectural protein, CTCF, is phosphorylated at Ser224 in a cell-cycle-dependent manner and abrogation of phosphorylation leads to a cell growth defect.
    1. Cell Biology

    Human VPS13A is associated with multiple organelles and influences mitochondrial morphology and lipid droplet motility

    Wondwossen M Yeshaw et al.
    VPS13A is associated with the endoplasmic reticulum, mitochondria and lipid droplets and is required for cellular processes that require interaction between these organells.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Non-invasive measurement of mRNA decay reveals translation initiation as the major determinant of mRNA stability

    Leon Y Chan et al.
    Non-invasive mRNA stability measurements reveal that transcript lifetime is governed by a competition with translation initiation on a transcriptome-wide level.