317 results found
    1. Genetics and Genomics

    Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994

    Aline Jelenkovic, Yoon-Mi Hur ... Karri Silventoinen
    Genetic variance of adult human height shows a generally increasing trend across the birth-year cohorts but heritability estimates do not present any clear pattern of secular changes over a century.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Risk factors affecting polygenic score performance across diverse cohorts

    Daniel Hui, Scott Dudek ... Marylyn D Ritchie
    Numerous related sample characteristics affect polygenic score performance, and incorporation of interaction effects increases both model and polygenic score performance.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Structure of the germline genome of Tetrahymena thermophila and relationship to the massively rearranged somatic genome

    Eileen P Hamilton, Aurélie Kapusta ... Robert S Coyne
    The model organism Tetrahymena thermopile carries two nuclei with distinct genomes: an unrearranged germline genome with five chromosomes, and a somatic genome reduced in size by a third and with 181 chromosomes.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Methylation of histone H3K23 blocks DNA damage in pericentric heterochromatin during meiosis

    Romeo Papazyan, Ekaterina Voronina ... Sean D Taverna
    A previously unappreciated histone methylation pathway helps limit DNA double-strand break formation and recombination in heterochromatin during meiosis.
    1. Biochemistry and Chemical Biology

    Z-REX uncovers a bifurcation in function of Keap1 paralogs

    Alexandra Van Hall-Beauvais, Jesse R Poganik ... Yimon Aye
    Two zebrafish Keap1-paralogs are equally adept at electrophile-sensing but manifest divergent and co-regulatory electrophile-signaling behaviors.
    1. Microbiology and Infectious Disease

    Maintenance of cell wall remodeling and vesicle production are connected in Mycobacterium tuberculosis

    Vivian Salgueiro, Jorge Bertol ... Rafael Prados-Rosales
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Convincing
    1. Ecology
    2. Evolutionary Biology

    Effects of domestication on the gut microbiota parallel those of human industrialization

    Aspen T Reese, Katia S Chadaideh ... Rachel N Carmody
    Gut microbial signatures of domestication parallel those of industrialization, implicating shared ecological drivers.
    1. Neuroscience

    Brain functional networks associated with social bonding in monogamous voles

    M Fernanda López-Gutiérrez, Zeus Gracia-Tabuenca ... Sarael Alcauter
    Brain functional connectivity shows a neurobiological predisposition to social bonding, and network-wide changes occur as a result of cohabitation in the prairie vole.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Simple biochemical features underlie transcriptional activation domain diversity and dynamic, fuzzy binding to Mediator

    Adrian L Sanborn, Benjamin T Yeh ... Roger D Kornberg
    Transcriptional activation domains achieve rapid, dynamic, specific interaction with Mediator through binding of an unstructured peptide to multiple hydrophobic surfaces without particular amino acid side chain interactions.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Decoding protein phosphorylation during oocyte meiotic divisions using phosphoproteomics

    Leonid Peshkin, Enrico Maria Daldello ... Catherine Jessus
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid

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