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    1. Biochemistry and Chemical Biology

    Fine interaction profiling of VemP and mechanisms responsible for its translocation-coupled arrest-cancelation

    Ryoji Miyazaki et al.
    Time-resolved and site-directed in vivo photo-crosslinking analysis of VemP allows identification of both cis- and trans-elements required for its regulated arrest-cancelation.
    1. Microbiology and Infectious Disease

    Bacterial symbiont subpopulations have different roles in a deep-sea symbiosis

    Tjorven Hinzke et al.
    Physiological differentiation during symbiosis leads to division of labor between smaller and larger cells in an uncultured bacterial tubeworm symbiont population and results in remarkable metabolic diversity and complexity.
    1. Structural Biology and Molecular Biophysics

    Structural insights into the nucleic acid remodeling mechanisms of the yeast THO-Sub2 complex

    Sandra K Schuller et al.
    The THO-Sub2 complex is an asymmetric homodimer that uses the spatial arrangement of two Sub2 helicases to prevent RNA:DNA hybrids.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Functional reconstitution of a bacterial CO2 concentrating mechanism in Escherichia coli

    Avi I Flamholz et al.
    A bacterial CO2 concentrating mechanism enables Escherichia coli to fix CO2 from ambient air into biomass.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Genetic Engineering: Increasing the uptake of carbon dioxide

    Eric Franklin, Martin Jonikas
    A mechanism for concentrating carbon dioxide has for the first time been successfully transferred into a species that lacks such a process.
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    1. Neuroscience

    The amygdala instructs insular feedback for affective learning

    Dominic Kargl et al.
    Hierarchical information flow in a cortico-limbic loop between the insular cortex, central amygdala and the cholinergic basal forebrain links bodily states with environmental stimuli to guide fear and reward behavior.
    1. Cancer Biology
    2. Immunology and Inflammation

    The effects of age and systemic metabolism on anti-tumor T cell responses

    Jefte M Drijvers et al.
    A comprehensive literature review delineates the current knowledge of how systemic context, such as age and obesity, can impact CD8+ T cell function, anti-tumor immunity, and immunotherapy responsiveness.
    1. Ecology
    2. Neuroscience

    BiteOscope, an open platform to study mosquito biting behavior

    Felix JH Hol et al.
    A new tool to visualize blood-feeding mosquitoes in high resolution and quantitatively characterize their behavior sheds light on contact-dependent sensing and blood-feeding dynamics of several medically relevant mosquito species.
    1. Developmental Biology
    2. Physics of Living Systems

    Size-dependent patterns of cell proliferation and migration in freely-expanding epithelia

    Matthew A Heinrich et al.
    Epithelia exhibit size-dependent growth dynamics caused by a decoupling between boundary and bulk cellular dynamics that enable robust expansion and drive cell cycling, collective migration, and tissue-spanning vortices.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    The NTP generating activity of pyruvate kinase II is critical for apicoplast maintenance in Plasmodium falciparum

    Russell P Swift et al.
    The pyruvate kinase contained in the apicoplast organelle of malaria parasites makes the nucleotide triphosphates required for several processes including transcription of the organellar genome.