2 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    SPRTN is a mammalian DNA-binding metalloprotease that resolves DNA-protein crosslinks

    Jaime Lopez-Mosqueda et al.
    SPRTN is a protease essential for the repair of cytotoxic DNA-protein cross links and this function is defective in patients afflicted with Ruijs-Aalfs syndrome -a segmental progeroid syndrome.
    1. Genetics and Genomics

    DNA damage—how and why we age?

    Matt Yousefzadeh et al.
    There is now sufficient and diverse evidence to support a cogent argument that DNA damage plays a causal role in aging.

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