8,564 results found
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Random sub-diffusion and capture of genes by the nuclear pore reduces dynamics and coordinates inter-chromosomal movement

    Michael Chas Sumner et al.
    Measuring and simulating chromatin dynamics reveals that repositioning of genes to the nuclear pore is neither active nor vectorial, but reduces sub-diffusion and coordinates movement between loci on different chromosomes.
    1. Developmental Biology
    2. Neuroscience

    Differential spatiotemporal development of Purkinje cell populations and cerebellum-dependent sensorimotor behaviors

    Gerrit Cornelis Beekhof et al.
    Different Purkinje cell subpopulations show distinct developmental profiles of physiological activity, climbing fiber inputs and axonal and dendritic morphology, matching different timelines of cerebellum-dependent behaviors.
    1. Epidemiology and Global Health

    High infectiousness immediately before COVID-19 symptom onset highlights the importance of continued contact tracing

    William S Hart et al.
    Fitting a mechanistic model to data from SARS-CoV-2 source-recipient pairs generates improved estimates of changes in infectiousness during infection, indicating substantial transmission shortly before symptom onset.
    1. Cancer Biology
    2. Cell Biology

    KSR1- and ERK-dependent translational regulation of the epithelial-to-mesenchymal transition

    Chaitra Rao et al.
    A key Ras-driven signaling pathway stimulates the preferential translation of an effector, EPSTI1, that is both necessary and sufficient for the epithelial-to-mesenchymal transition-like phenotype in colorectal cancer cells.
    1. Cell Biology

    An in vivo reporter for tracking lipid droplet dynamics in transparent zebrafish

    Dianne Lumaquin et al.
    A novel transgenic lipid droplet reporter in transparent casper zebrafish allows direct visualization of individual lipid droplets in a living animal.
    1. Cell Biology

    Micron-scale geometrical features of microtubules as regulators of microtubule organization

    Nandini Mani et al.
    Micron-scale geometrical features of individual microtubule polymers and polymer networks encode information that guides the self-organization of microtubules into specialized structures for diverse cellular functions such as cell division and signaling in eukaryotic cells.
    1. Cancer Biology

    A systematic CRISPR screen reveals an IL-20/IL20RA-mediated immune crosstalk to prevent the ovarian cancer metastasis

    Jia Li et al.
    A genome-wide in vivo CRISPR screen identifies an IL-20/IL20RA-mediated crosstalk between peritoneum mesothelial cells and ovarian cancer cells that promotes the formation of M1-like macrophages to prevent ovarian cancer metastasis.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Detecting adaptive introgression in human evolution using convolutional neural networks

    Graham Gower et al.
    Convolutional neural networks are an effective tool for detecting archaic adaptive introgression from genomic data.
    1. Cell Biology
    2. Developmental Biology

    Canonical NF-κB signaling maintains corneal epithelial integrity and prevents corneal aging via retinoic acid

    Qian Yu et al.
    Corneal aging is regulated by the NF-κB-retinoic acid pathway and can be delayed by retinoic acid administration.
    1. Cancer Biology

    Phenotypic plasticity underlies local invasion and distant metastasis in colon cancer

    Andrea Sacchetti et al.
    Colon cancer cells disseminate and colonize distant organ sites along the invasion-metastasis cascade by transiently activating intermediate epithelial to mesenchymal transition states through distinct transcriptional trajectories.

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