6,281 results found
    1. Ecology

    Echolocating toothed whales use ultra-fast echo-kinetic responses to track evasive prey

    Heather Vance et al.
    Echolocating toothed whales can detect and react to sudden prey movements during close approaches with speeds similar to ultra-fast tracking responses in human vision.
    1. Medicine

    Infrared molecular fingerprinting of blood-based liquid biopsies for the detection of cancer

    Marinus Huber et al.
    The combination of molecular infrared fingerprinting and machine learning enables the detection of breast, bladder, prostate, and lung cancer based on liquid blood serum and plasma, providing a general framework for the minimally invasive investigation of oncological conditions.
    1. Neuroscience

    Septal cholinergic input to CA2 hippocampal region controls social novelty discrimination via nicotinic receptor-mediated disinhibition

    Domenico Pimpinella et al.
    Acetylcholine, released from cholinergic fibers originating from the medial septum, shapes social memory, and controls the CA2 hippocampal circuit via nicotinic receptors localized on GABAergic interneurons.
    1. Microbiology and Infectious Disease

    Pathogen clonal expansion underlies multiorgan dissemination and organ-specific outcomes during murine systemic infection

    Karthik Hullahalli, Matthew K Waldor
    During Escherichia coli systemic infection, the replication of a minuscule fraction of the inoculum drives organ-specific clearance failures, systemic dissemination, and stochastic infection outcomes.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    mRNA vaccine-induced T cells respond identically to SARS-CoV-2 variants of concern but differ in longevity and homing properties depending on prior infection status

    Jason Neidleman et al.
    COVID-19 mRNA vaccine-elicited T cells recognize variants of concern and phenotypically differ depending on number of vaccine doses and prior SARS-CoV-2 infection status.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    The Lon protease temporally restricts polar cell differentiation events during the Caulobacter cell cycle

    Deike J Omnus et al.
    A proteomics-based approach identifies novel substrate proteins of the Lon protease in Caulobacter crescentus and reveals a critical role of Lon in regulating flagella assembly and stalk biogenesis during the cell cycle.
    1. Microbiology and Infectious Disease

    Effect of SARS-CoV-2 proteins on vascular permeability

    Rossana Rauti et al.
    A specific SARS-CoV-2 proteins that affect the vascular permeability and impairs the functionality of other significant organs has been identified.
    1. Ecology

    Little evidence that Eurasian jays protect their caches by responding to cues about a conspecific’s desire and visual perspective

    Piero Amodio et al.
    Across five experiments, Eurasian jays’ caching behaviour provides little evidence of the ability to integrate cues about a potential pilferer’s visual perspective and desire and, challenging previous findings, to respond to either of the two social cues independently.
    1. Neuroscience

    A state space modeling approach to real-time phase estimation

    Anirudh Wodeyar et al.
    A statistically principled approach developed to estimate phase of rhythmic signals in real-time shows robustness to multiple sources of error and also provides confidence criteria.
    1. Structural Biology and Molecular Biophysics

    Transcription initiation at a consensus bacterial promoter proceeds via a ‘bind-unwind-load-and-lock’ mechanism

    Abhishek Mazumder et al.
    Single-molecule fluorescence experiments reveal transcription initiation proceeds via a 'bind-unwind-load-and-lock' mechanism where promoter DNA unwinds outside the RNA polymerase (RNAP) cleft, the unwound template-DNA loads into the cleft, and RNAP 'locks' the template-DNA by closing the RNAP clamp module.

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