623 results found
    1. Developmental Biology
    2. Genetics and Genomics

    The rosetteless gene controls development in the choanoflagellate S. rosetta

    Tera C Levin et al.
    The establishment of forward genetics in S. rosetta reveals the first gene known to be required for choanoflagellate multicellular development.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Predicted glycosyltransferases promote development and prevent spurious cell clumping in the choanoflagellate S. rosetta

    Laura A Wetzel et al.
    A genetic screen reveals that two predicted glycosyltransferases promote rosette development and prevent cell clumping in one of the closest living relatives of animals, the choanoflagellate S. rosetta.
    1. Physics of Living Systems

    Aerotaxis in the closest relatives of animals

    Julius B Kirkegaard et al.
    The colony-forming choanoflagellate Salpingoeca rosetta is capable of moving towards oxygen using logarithmic sensing of oxygen concentrations and a navigation strategy that involves random movements.
    1. Evolutionary Biology

    Gene family innovation, conservation and loss on the animal stem lineage

    Daniel J Richter et al.
    The genomes of animal progenitors evolved as mosaics of old, new, rearranged, and repurposed protein domains, genes and pathways and paved the way for the origin and evolution of animals.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Molecular mechanism of activation-triggered subunit exchange in Ca2+/calmodulin-dependent protein kinase II

    Moitrayee Bhattacharyya et al.
    Closed-ring and open-spiral assembly of the multi-subunit neuronal kinase CaMKII suggest a mechanism for how active subunits shuttle between individual assemblies, propagating stimulatory signals.
    1. Cell Biology

    A bacterial sulfonolipid triggers multicellular development in the closest living relatives of animals

    Rosanna A Alegado et al.
    The development of colonies of cells in choanoflagellates, water-dwelling organisms that feed on bacteria, is triggered by the presence of very low concentrations of a lipid molecule produced by certain types of bacteria.
    1. Developmental Biology
    2. Genetics and Genomics

    Genome editing enables reverse genetics of multicellular development in the choanoflagellate Salpingoeca rosetta

    David S Booth, Nicole King
    Genome editing in the choanoflagellate Salpingoeca rosetta opens newfound possibilities to functionally probe choanoflagellate genes that may illuminate the origin of their closest relatives, the animals.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Affimer proteins are versatile and renewable affinity reagents

    Christian Tiede et al.
    The Affimer technology represents renewable binding reagents for molecular biology, which provides research scientists and industry with an alternative to the recently criticised use of animal-produced antibodies.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Molecular mechanism of Aurora A kinase autophosphorylation and its allosteric activation by TPX2

    Adelajda Zorba et al.
    Aurora A kinase, an anti-cancer drug target, can be activated by two independent mechanisms.
    1. Cell Biology
    2. Developmental Biology

    Zebrafish Posterior Lateral Line primordium migration requires interactions between a superficial sheath of motile cells and the skin

    Damian E Dalle Nogare et al.
    Epithelial cells utilize a covering sheath of motile cells to migrate in confinement.

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