The SAGA complex binds non-chromosomal DNA circles and prevents their spreading by attaching them to nuclear pores, thereby leading to the concomitant accumulation of DNA circles and pores in ageing yeast mother cells.

An atomic model of the 3744-residue Tra1 protein reveals multiple transcription activator binding sites, its integration within the SAGA chromatin coactivator complex, and a striking similarity to DNA-repair factor DNA-PKcs.

An unbiased biochemical screen reveals a direct link between gene regulation and actin cytoskeleton remodeling.

Cumulative exposure to adverse childhood experiences is associated with lower adult resilience among women in a dose-dependent manner, independent of adult socioeconomic factors and social support, indicating that adult female resilience is consolidated in early life.

A transcriptional coactivator turns into a repressor at specific genes in colorectal cancer cells.

Acetylation of nuclear basket components, following their interaction with accumulating extrachromosomal DNA circles, drives the reorganization of nuclear pore complexes and the loss of cellular viability associated with replicative ageing.

Light signaling components interact with a histone H2B deubiquitination module, adjusting chromatin states at global level during Arabidopsis seedling development.

In filamentous fungi the AP-2 complex, which in mammals is an adaptor of clathrin-mediated endocytosis, is recruited to specific clathrin-independent apical endocytosis necessary for proper lipid maintenance and polar growth.

The core of histone acetyltransferase complex, NuA4, flexibly tethers various histone recognition modules, including the HAT module which is capable of binding nucleosomes marked by H3K4me3 and H3 acetylation.

The transcription coactivators SAGA and TFIID have redundant function at a subset of yeast genes while SAGA also contributes to transcription of all genes through regulation of chromatin modifications.