201 results found
    1. Human Biology and Medicine

    Endothelial heterogeneity across distinct vascular beds during homeostasis and inflammation

    Ankit Jambusaria et al.
    Vascular endothelial cells in the brain, heart and lung exhibit tissue-specific heterogeneity and plasticity, expressing genes that were traditionally thought to be only expressed by the surrounding parenchymal tissue cells.
    1. Cell Biology
    2. Developmental Biology

    Hair follicle stem cells regulate retinoid metabolism to maintain the self-renewal niche for melanocyte stem cells

    Zhiwei Lu et al.
    Metabolite mediates communication between stem cells and influences stem cell maintenance.
    1. Cancer Biology
    2. Developmental Biology

    Regulation of zebrafish melanocyte development by ligand-dependent BMP signaling

    Alec K Gramann et al.
    The oncogenic role ligand-dependent BMP signaling plays in suppressing differentiation in melanoma is a reiteration of its physiological roles during melanocyte development.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Common activation mechanism of class A GPCRs

    Qingtong Zhou et al.
    Contrary to previous findings, class A GPCRs share a common activation pathway that directly links ligand binding to G-protein activation, as revealed by novel quantitative analysis.
    1. Neuroscience

    Local cortical desynchronization and pupil-linked arousal differentially shape brain states for optimal sensory performance

    Leonhard Waschke et al.
    The momentary levels of local cortical desynchronization and pupil-linked arousal pose dissociable influences not only on the processing of sensory information but also on human perceptual performance.
    1. Biochemistry and Chemical Biology

    Exchange of water for sterol underlies sterol egress from a StARkin domain

    George Khelashvili et al.
    The capture and export of a hydrophobic sterol molecule from the binding pocket of a Lam/GramD1 sterol-binding protein is unexpectedly mediated by water.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Extraction of active RhoGTPases by RhoGDI regulates spatiotemporal patterning of RhoGTPases

    Adriana E Golding et al.
    Through visualization of directly-labeled RhoGTPase both in vitro and in vivo, RhoGDI is found to spatiotemporally regulate RhoGTPase activity through the extraction of active RhoGTPase.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Movement of accessible plasma membrane cholesterol by the GRAMD1 lipid transfer protein complex

    Tomoki Naito et al.
    GRAMD1 proteins sense a transient expansion of the accessible pool of plasma membrane cholesterol and facilitate its transport to the endoplasmic reticulum at ER-PM contact sites.
    1. Neuroscience

    Alpha/beta power decreases track the fidelity of stimulus-specific information

    Benjamin James Griffiths et al.
    Neural representations of stimulus-specific information increase in fidelity as the power of alpha/beta activity decreases, suggesting that alpha/beta power decreases reflect a domain-general mechanism that supports information representation.

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