3,337 results found
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Science Forum: SARS-CoV-2 (COVID-19) by the numbers

    Yinon M Bar-On et al.
    Key numbers about the biology of the SARS-CoV-2 virus and the infection of a single human host by the virus have been compiled from the peer-reviewed literature.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Viruses: Neutralizing SARS-CoV-2

    Eric Poeschla
    Experiments with hybrid viruses are illuminating how SARS-CoV-2 can escape neutralizing antibodies.
    Insight
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    1. Epidemiology and Global Health

    Differential occupational risks to healthcare workers from SARS-CoV-2 observed during a prospective observational study

    David W Eyre et al.
    Risk factors for SARS-CoV-2 infection in healthcare workers included caring for Covid-19 patients, Black or Asian ethnicity, and Covid-19-positive household contacts, whereas a bundle of PPE-related measures protected ICU staff.
    1. Microbiology and Infectious Disease

    Antibodies to SARS-CoV-2 and their potential for therapeutic passive immunization

    PJ Klasse, John P Moore
    Antibodies hold promise for breakthrough treatment of COVID-19, the disease caused by the coronavirus SARS-CoV-2.
    1. Epidemiology and Global Health
    2. Medicine

    Effective control of SARS-CoV-2 transmission between healthcare workers during a period of diminished community prevalence of COVID-19

    Nick K Jones et al.
    Diminished incidence of COVID-19 amongst healthcare workers in a comprehensive screening programme demonstrates how effective infection control measures and staff testing can prevent hospitals becoming independent 'hubs' of SARS-CoV-2 transmission.
    1. Microbiology and Infectious Disease

    SARS-CoV-2 entry into human airway organoids is serine protease-mediated and facilitated by the multibasic cleavage site

    Anna Z Mykytyn et al.
    Whereas SARS-CoV-2 utilizes cathepsins to enter most cell lines, human airway organoids revealed that entry into relevant cells is dependent on serine proteases, which can be targeted for treatment.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure of the SAS-6 cartwheel hub from Leishmania major

    Mark van Breugel et al.
    The X-ray structure of the SAS-6 cartwheel hub from Leishmania major demonstrates that SAS-6 can be sufficient to determine centriolar cartwheel symmetry.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Dynamically evolving novel overlapping gene as a factor in the SARS-CoV-2 pandemic

    Chase W Nelson et al.
    A novel, overlapping, putatively functional gene in SARS-CoV-2, ORF3d, is absent from close relatives of SARS-CoV-2 and may have contributed to the biology, emergence, or spread of the virus.
    1. Epidemiology and Global Health
    2. Medicine

    Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission

    Lucy Rivett et al.
    3% of >1,000 asymptomatic healthcare workers in their workplace tested positive for SARS-CoV-2, suggesting that comprehensive screening programmes are vital to prevent acquisition of COVID-19 in hospitals.
    1. Epidemiology and Global Health

    Quantifying antibody kinetics and RNA detection during early-phase SARS-CoV-2 infection by time since symptom onset

    Benny Borremans et al.
    A meta-analysis shows that seroconversion of antibodies against SARS-CoV-2 is not affected by disease severity and finds higher viral RNA detection probability in lower respiratory tract and fecal samples.

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