3,266 results found
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Drivers and sites of diversity in the DNA adenine methylomes of 93 Mycobacterium tuberculosis complex clinical isolates

    Samuel J Modlin et al.
    Fully assembled DNA methylomes from phylogeographically diverse clinical Mycobacterium tuberculosis complex isolates reveals 'intercellular mosaic methylation' as a source of epigenetic diversity.
    1. Neuroscience

    Vascular control of the CO2/H+-dependent drive to breathe

    Colin M Cleary et al.
    Understanding how loss of CO2/H+ vascular reactivity affects respiratory control may facilitate development of treatments for breathing problems in this population.
    1. Computational and Systems Biology

    In-depth human plasma proteome analysis captures tissue proteins and transfer of protein variants across the placenta

    Maria Pernemalm et al.
    Comprehensive mass spectrometry analysis of human plasma proteome reveals tissue leakage proteins, describes variability between individual plasma proteomes and demonstrates protein transfer across the placenta during pregnancy.
    1. Neuroscience

    Pro-death NMDA receptor signaling is promoted by the GluN2B C-terminus independently of Dapk1

    Jamie McQueen et al.
    Excitotoxicity driven by NMDA receptor hyper-activation does not involve DAPK1-dependent events in vitro or in vivo, and previously described DAPK1-NMDAR disrupting peptides act by blocking the NMDA receptor.
    1. Immunology and Inflammation

    T cell immunodominance is dictated by the positively selecting self-peptide

    Wan-Lin Lo et al.
    The T cell repertoire can display immunodominance to an epitope as a result of optimal positive selection in the thymus by one self-peptide/MHC ligand.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Structured illumination with particle averaging reveals novel roles for yeast centrosome components during duplication

    Shannon Burns et al.
    Visualization of yeast spindle pole proteins using a new microscopy method shows that assembly into the nuclear membrane occurs at the same time as duplication.
    1. Neuroscience

    Cell autonomous regulation of hippocampal circuitry via Aph1b-γ-secretase/neuregulin 1 signalling

    Pietro Fazzari et al.
    Genetic rescue experiments reveal that γ-secretase enzymes containing Aph1b subunits control signalling by type III neuregulin 1, with implications for schizophrenia.
    1. Stem Cells and Regenerative Medicine

    Stochastic homeostasis in human airway epithelium is achieved by neutral competition of basal cell progenitors

    Vitor H Teixeira et al.
    Cell replenishment within the airways is governed by the random division of a population of basal progenitor cells, in a process that is accelerated in smokers.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Histone gene replacement reveals a post-transcriptional role for H3K36 in maintaining metazoan transcriptome fidelity

    Michael P Meers et al.
    Post-translational modification of histone H3K36 is not required to suppress cryptic transcription initiation or to include alternative exons in Drosophila; instead it promotes expression of active genes by stimulating polyadenylation.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    RAGE deficiency predisposes mice to virus-induced paucigranulocytic asthma

    Jaisy Arikkatt et al.
    HMGB1 drives the development of paucigranulocytic asthma in RAGE deficient mice.

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