254 results found
    1. Human Biology and Medicine

    Inflammatory osteolysis is regulated by site-specific ISGylation of the scaffold protein NEMO

    Naga Suresh Adapala et al.
    Site-specific modification of NEMO facilitates RANKL signal specificity in myeloid progenitors and serves as a potential target to modulate inflammatory osteolysis through ISG15-dependent autophagy.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Targeting mir128-3p alleviates myocardial insulin resistance and prevents ischemia-induced heart failure

    Andrea Ruiz-Velasco et al.
    Targeting mir128-3p could prevent cardiac insulin resistance in the non-infarcted myocardium and limit cardiac injury after myocardial infarction, delaying the development of heart failure.
    1. Immunology and Inflammation

    Tumors attenuating the mitochondrial activity in T cells escape from PD-1 blockade therapy

    Alok Kumar et al.
    Downregulation of mitochondrial activity by immunosuppressive tumor-derived soluble factors leads to systemic unresponsiveness to the PD-1 blockade therapy.
    1. Immunology and Inflammation

    Rejuvenating conventional dendritic cells and T follicular helper cell formation after vaccination

    Marisa Stebegg et al.
    Older individuals have impaired conventional dendritic cell and T follicular helper cell formation upon vaccination, which can be rescued by treatment with a TLR7 agonist.
    1. Developmental Biology

    Enhanced ER-associated degradation of HMG CoA reductase causes embryonic lethality associated with Ubiad1 deficiency

    Youngah Jo et al.
    Embryonic lethality associated with deficiency of UBIAD1, which synthesizes a vitamin K2 subtype, results from aberrant ER-associated degradation of the cholesterol biosynthetic enzyme HMG CoA reductase.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Metabolic and non-metabolic liver zonation is established non-synchronously and requires sinusoidal Wnts

    Ruihua Ma et al.
    Mouse genetic approaches show that multiple Wnt endothelial sources orchestrate the spatiotemporal distribution of hepatocyte functions during liver maturation and respecify metabolic zonation during liver repair.
    1. Immunology and Inflammation

    A novel role for lipoxin A4 in driving a lymph node–eye axis that controls autoimmunity to the neuroretina

    Jessica Wei et al.
    LXA4 in lymph nodes is an important resident homeostatic regulator that controls effector T cell functions and egress in the development of adaptive immune responses.
    1. Immunology and Inflammation

    Thioredoxin-1 distinctly promotes NF-κB target DNA binding and NLRP3 inflammasome activation independently of Txnip

    Jonathan Muri et al.
    The thioredoxin-1 (Trx1) system promotes inflammation by positively regulating both NLRP3 inflammasome responses, by detoxifying excessive ROS independently of Txnip and NF-κB binding to target DNA.
    1. Immunology and Inflammation

    Anti-PD-1 immunotherapy leads to tuberculosis reactivation via dysregulation of TNF-α

    Liku B Tezera et al.
    Immune checkpoint inhibition therapy for cancer paradoxically activates tuberculosis infection, and advanced human cell culture modelling demonstrates excess TNF-α section is the primary driver.
    1. Chromosomes and Gene Expression

    Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta

    Eric Engelbrecht et al.
    The sphingosine 1-phosphate receptor-1 (S1PR1) signals in heterogenous populations of mouse adventitial lymphatic (LEC) and arterial endothelial cells (aEC1, aEC2) to regulate chromatin and the transcriptome, thus affecting their phenotypes.

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