335 results found
    1. Genetics and Genomics

    Expression of SREBP-1c Requires SREBP-2-mediated Generation of a Sterol Ligand for LXR in Livers of Mice

    Shunxing Rong et al.
    SREBP-2 directly regulates genes involved in cholesterol homeostasis and indirectly regulates fatty acid synthesis through the production of a ligand responsible for the activation of LXR and SREBP-1c.
    1. Cancer Biology
    2. Cell Biology

    The ESRP1-GPR137 axis contributes to intestinal pathogenesis

    Lukas Franz Mager et al.
    ESRP1 is central to intestinal barrier integrity in mice and humans and alterations in ESRP1 function or expression contribute to intestinal pathology, partly through modified expression of ESRP1-specific GPR137 isoforms.
    1. Cell Biology

    BHLHE40, a third transcription factor required for insulin induction of SREBP-1c mRNA in rodent liver

    Jing Tian et al.
    Biochemical and genetic studies reveal a third transcription factor, BHLHE40, that together with LXR and C/EBPβ mediates insulin induction of SREBP-1c, which in turn leads to triglyceride accumulation in liver.
    1. Neuroscience

    Stxbp1/Munc18-1 haploinsufficiency impairs inhibition and mediates key neurological features of STXBP1 encephalopathy

    Wu Chen et al.
    Two genetically distinct Stxbp1 haploinsufficiency mouse models exhibit seizures and impairments in cognitive, psychiatric, and motor functions, representing robust preclinical models of STXBP1 encephalopathy with both construct and face validity.
    1. Structural Biology and Molecular Biophysics

    Allosteric activation of SENP1 by SUMO1 β-grasp domain involves a dock-and-coalesce mechanism

    Jingjing Guo, Huan-Xiang Zhou
    Simulations of molecular dynamics suggest how the binding of the β-grasp domain of SUMO1 induces conformational and dynamic effects to activate SENP1.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    The splicing regulators Esrp1 and Esrp2 direct an epithelial splicing program essential for mammalian development

    Thomas W Bebee et al.
    Large-scale developmental defects in mice occur with the ablation of the epithelial-specific splicing factors Esrp1 and Esrp2.
    1. Biochemistry and Chemical Biology

    Characterisation of the biflavonoid hinokiflavone as a pre-mRNA splicing modulator that inhibits SENP

    Andrea Pawellek et al.
    Hinokiflavone is identified as a splicing modulator that blocks progression from spliceosome complex A to complex B and inhibits SUMO protease SENP1, causing hyper-SUMOylation affecting 6 U2 snRNP proteins.
    1. Neuroscience

    Increased expression of heme-binding protein 1 early in Alzheimer's disease is linked to neurotoxicity

    Oleksandr Yagensky et al.
    Increased levels of brain Hebp1 starting from the presymptomatic stage of Alzheimer’s disease contributes to progressive neuronal loss by triggering mitochondrial-dependent apoptosis in neurons exposed to elevated heme.
    1. Genetics and Genomics

    Comparative genetic screens in human cells reveal new regulatory mechanisms in WNT signaling

    Andres M Lebensohn et al.
    A systematic genetic analysis comprising seven genome-wide screens in haploid human cells uncovered new regulatory mechanisms at most levels in the WNT signaling pathway.
    1. Cell Biology

    Prolyl dihydroxylation of unassembled uS12/Rps23 regulates fungal hypoxic adaptation

    Sara J Clasen et al.
    The protein uS12/Rps23 functions extra-ribosomally to control oxygen homeostasis in fission yeast.

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