3,863 results found
    1. Microbiology and Infectious Disease

    Evolutionary consequences of intra-patient phage predation on microbial populations

    Kimberley D Seed, Minmin Yen ... Andrew Camilli
    Bacterial viruses are an unexpected ‘third party’ that imposes a strong predatory pressure on a bacterial pathogen during the natural course of infection in humans.
    1. Microbiology and Infectious Disease

    A chimeric nuclease substitutes a phage CRISPR-Cas system to provide sequence-specific immunity against subviral parasites

    Zachary K Barth, Maria HT Nguyen, Kimberley D Seed
    Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome parasite-mediated restriction.
    1. Ecology
    2. Evolutionary Biology

    CRISPR-based herd immunity can limit phage epidemics in bacterial populations

    Pavel Payne, Lukas Geyrhofer ... Jonathan P Bollback
    Bacteria can exhibit herd immunity protection against phages, which may play a significant role in their ecology and evolution.
    1. Computational and Systems Biology
    2. Developmental Biology

    Modularity, criticality, and evolvability of a developmental gene regulatory network

    Berta Verd, Nicholas AM Monk, Johannes Jaeger
    A new approach focusing on dynamic modularity helps overcome traditional challenges detecting modularity in complex adaptive systems.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    A Vibrio cholerae viral satellite maximizes its spread and inhibits phage by remodeling hijacked phage coat proteins into small capsids

    Caroline M Boyd, Sundharraman Subramanian ... Kimberley D Seed
    A phage parasite encodes an external scaffolding protein to pirate and rearrange phage-encoded coat proteins to more efficiently transfer the phage parasite genome to new hosts and limit phage production.
    1. Neuroscience

    Selective increases in inter-individual variability in response to environmental enrichment in female mice

    Julia C Körholz, Sara Zocher ... Gerd Kempermann
    The classical experimental paradigm of "enriched environments" is repositioned as a tool to address the question of how behavioral activity and the environment contribute to specific differences between individuals.
    1. Microbiology and Infectious Disease

    Dominant Vibrio cholerae phage exhibits lysis inhibition sensitive to disruption by a defensive phage satellite

    Stephanie G Hays, Kimberley D Seed
    Genetic and molecular analyses identify and characterize an evolutionary battle over lysis timing wherein a bacteriophage delays lysis through lysis inhibition while a defensive phage satellite accelerates lysis.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    High-resolution mapping of the neutralizing and binding specificities of polyclonal sera post-HIV Env trimer vaccination

    Adam S Dingens, Payal Pratap ... Jesse D Bloom
    HIV vaccine-induced binding and neutralizing antibody epitope specificities were mapped at high resolution directly from polyclonal sera, overcoming shortcomings in traditional serum mapping approaches and enabling highly detailed vaccine design.
    1. Immunology and Inflammation

    Intraocular dendritic cells characterize HLA-B27-associated acute anterior uveitis

    Maren Kasper, Michael Heming ... Gerd Meyer zu Hörste
    Single-cell transcriptomics of intraocular infiltrate in human HLA-B27-associated active anterior uveitis shows a unique composition and phenotype of leukocytes preferentially affecting dendritic cells.
    1. Biochemistry and Chemical Biology

    Tyr1 phosphorylation promotes phosphorylation of Ser2 on the C-terminal domain of eukaryotic RNA polymerase II by P-TEFb

    Joshua E Mayfield, Seema Irani ... Yan Zhang
    The phosphorylation of tyrosine in the heptad repeat of the C-terminal domain of the largest subunit of RNA polymerase II promotes Ser2 phosphorylation by P-TEFb for pausing release.

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