Friedrich Schuessler, Francesca Mastrogiuseppe ... Omri Barak
An analysis of the relation between neural activity and behavioral output uncovers two dynamical regimes, shows how to model them, and demonstrates how to find them in experimental data.
The GABA input switching from excitatory to inhibitory during maturation of adult-born dentate granule cells is crucial for their integration into the preexisting circuit.
Separating behaviorally relevant signals from irrelevant signals reveals that neural signals previously considered to contain little information encode rich information and suggests that linear readout may be performed in motor cortex.
Preimplantation screening of embryos using polygenic risk scores may substantially reduce risk for a given complex disease, but this effect depends on several quantifiable factors and raises significant ethical issues.
Sinisa Pajevic, Dietmar Plenz ... R Douglas Fields
A biologically plausible model of myelin plasticity demonstrates how oligodendrocytes can selectively adjust conduction delays in axon bundles to allow robust communication between brain regions through long-range synchronization.
Theoretical study shows how enzymes can achieve substrate proofreading by taking advantage of existing molecular gradients in the cell while not being endowed with structural features typically required for proofreading.