11,539 results found
    1. Computational and Systems Biology

    Efficient coding in biophysically realistic excitatory-inhibitory spiking networks

    Veronika Koren, Simone Blanco Malerba ... Stefano Panzeri
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Neuroscience

    Aligned and oblique dynamics in recurrent neural networks

    Friedrich Schuessler, Francesca Mastrogiuseppe ... Omri Barak
    An analysis of the relation between neural activity and behavioral output uncovers two dynamical regimes, shows how to model them, and demonstrates how to find them in experimental data.
    1. Computational and Systems Biology
    2. Neuroscience

    A functional model of adult dentate gyrus neurogenesis

    Olivia Gozel, Wulfram Gerstner
    The GABA input switching from excitatory to inhibitory during maturation of adult-born dentate granule cells is crucial for their integration into the preexisting circuit.
    1. Neuroscience

    Revealing unexpected complex encoding but simple decoding mechanisms in motor cortex via separating behaviorally relevant neural signals

    Yangang Li, Xinyun Zhu ... Yueming Wang
    Separating behaviorally relevant signals from irrelevant signals reveals that neural signals previously considered to contain little information encode rich information and suggests that linear readout may be performed in motor cortex.
    1. Developmental Biology
    2. Neuroscience

    Age-associated changes in lineage composition of the enteric nervous system regulate gut health and disease

    Subhash Kulkarni, Monalee Saha ... Pankaj Jay Pasricha
    Mesoderm-derived enteric neurons born in the post-natal vertebrates drive maturation and aging of the enteric nervous system.
    1. Genetics and Genomics

    Utility of polygenic embryo screening for disease depends on the selection strategy

    Todd Lencz, Daniel Backenroth ... Shai Carmi
    Preimplantation screening of embryos using polygenic risk scores may substantially reduce risk for a given complex disease, but this effect depends on several quantifiable factors and raises significant ethical issues.
    1. Neuroscience

    Oligodendrocyte-mediated myelin plasticity and its role in neural synchronization

    Sinisa Pajevic, Dietmar Plenz ... R Douglas Fields
    A biologically plausible model of myelin plasticity demonstrates how oligodendrocytes can selectively adjust conduction delays in axon bundles to allow robust communication between brain regions through long-range synchronization.
    1. Cell Biology

    Stratification of enterochromaffin cells by single-cell expression analysis

    Yan Song, Linda J. Fothergill ... Gene W. Yeo
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Microbiology and Infectious Disease

    Maintenance of cell wall remodeling and vesicle production are connected in Mycobacterium tuberculosis

    Vivian Salgueiro, Jorge Bertol ... Rafael Prados-Rosales
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Convincing
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Proofreading through spatial gradients

    Vahe Galstyan, Kabir Husain ... Rob Phillips
    Theoretical study shows how enzymes can achieve substrate proofreading by taking advantage of existing molecular gradients in the cell while not being endowed with structural features typically required for proofreading.

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