The size of a subcellular structure, yeast actin cables, scales with the linear dimensions of the cell, which is achieved by feedback control of their growth rate.
Sophie R Sichel, Benjamin P Bratton, Nina R Salama
The helical cell shape of Helicobacter pylori depends on the polymerizing cytoskeletal protein CcmA’s recruitment to the cell envelope by Csd5 and CcmA’s indirect stabilization of a periplasmic cell wall hydrolase via interactions with the transmembrane protein Csd7.
Melissa J Sharpe, Hannah M Batchelor, Geoffrey Schoenbaum
Preconditioned cues provide information about an associative model but do not, by default, trigger representations of value, either model-based or model-free.
Integrated single-cell and spatial genomics provides the first molecular map of the human oral mucosa and reveals a novel pro-inflammatory fibroblast involved in disease progression.
Austin H Patton, Emilie J Richards ... Christopher H Martin
Hybridization not only generates genetic diversity, but this diversity can alter the shape of the fitness landscape, changing which genotypic combinations are favored by natural selection and which accessible genotypic paths lead to novel fitness peaks.
Jennifer A Taylor, Benjamin P Bratton ... Nina R Salama
The helical bacterium Helicobacter pylori patterns cell wall synthesis using two distinct cytoskeletal proteins, CcmA and MreB, to achieve its characteristic shape.
Gareth W Fearnley, Katherine A Young ... Hayley J Sharpe
Systematic proteomic approaches identify several cell junction regulators as substrates for the homophilic receptor tyrosine phosphatase PTPRK and implicate its pseudophosphatase domain in substrate recognition.
Jefte M Drijvers, Arlene H Sharpe, Marcia C Haigis
A comprehensive literature review delineates the current knowledge of how systemic context, such as age and obesity, can impact CD8+ T cell function, anti-tumor immunity, and immunotherapy responsiveness.
