294 results found
    1. Cancer Biology
    2. Cell Biology

    Many si/shRNAs can kill cancer cells by targeting multiple survival genes through an off-target mechanism

    William Putzbach et al.
    Loading of CD95 and CD95L-derived sequences into the RNA-induced silencing complex elicits a distinct form of RNAi-mediated cell death of cancer cells that results from the targeting of multiple survival genes.
    1. Genetics and Genomics
    2. Neuroscience

    Behavioral Inheritance: When mothers leave their mark

    Raquel Barajas-Azpeleta, Kausik Si
    Progeny can inherit parental experiences through altered brain chemistry.
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    1. Neuroscience

    The causal role of the somatosensory cortex in prosocial behaviour

    Selene Gallo et al.
    A combination of human imaging and brain stimulation techniques show that the somatosensory cortex is essential to prosocial decision making, by transforming observed pain in accurate perception of others' distress.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Two-step membrane binding by the bacterial SRP receptor enable efficient and accurate Co-translational protein targeting

    Yu-Hsien Hwang Fu et al.
    Single molecule microscopy combined with biochemical analyses show that a two-step lipid-binding mechanism of the SRP receptor balances the trade-off between speed and specificity during co-translational protein targeting.
    1. Neuroscience

    MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders

    Adam J Harrington et al.
    Mice that lack the autism- and schizophrenia-linked gene MEF2C in cortical neurons have an imbalance of excitatory and inhibitory synapses, and impaired social and cognitive abilities.
    1. Plant Biology

    A chloroplast retrograde signal, 3’-phosphoadenosine 5’-phosphate, acts as a secondary messenger in abscisic acid signaling in stomatal closure and germination

    Wannarat Pornsiriwong et al.
    Molecular signals from chloroplasts can synergistically interact with the plant hormone, abscisic acid (ABA), to regulate non-canonical signaling pathways mediating fundamental cellular processes including stomatal closure, seed dormancy and germination.
    1. Cancer Biology

    TP53 drives invasion through expression of its Δ133p53β variant

    Gilles Gadea et al.
    Clinical analysis corroborated with experimental data demonstrate that Δ133p53β, a naturally occurring isoform of p53 protein, induces a pro-metastatic program and is a clinical indicator of metastasis, independently of TP53 mutation status.
    1. Neuroscience

    Sloppy morphological tuning in identified neurons of the crustacean stomatogastric ganglion

    Adriane G Otopalik et al.
    Reliable neuronal physiology can arise from variable and inefficient morphologies.
    1. Neuroscience

    Extracting grid cell characteristics from place cell inputs using non-negative principal component analysis

    Yedidyah Dordek et al.
    Computational modeling of the brain’s navigation system reveals that place cells can drive the formation of hexagonal patterns experimentally observed in grid cells activity.

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