727 results found
    1. Cancer Biology

    SPIN1 promotes tumorigenesis by blocking the uL18 (universal large ribosomal subunit protein 18)-MDM2-p53 pathway in human cancer

    Ziling Fang et al.
    SPIN1, a nucleolar protein, plays an oncogenic role by suppressing the tumor suppressor p53's function via regulation of the uL18-MDM2-p53 pathway.
    1. Developmental Biology

    Dissecting the pre-placodal transcriptome to reveal presumptive direct targets of Six1 and Eya1 in cranial placodes

    Nick Riddiford, Gerhard Schlosser
    RNA sequencing of the African clawed frog has identified hundreds of putative direct Six1 and Eya1 target genes, including transcriptional regulators of neuronal progenitors and neuronal/sensory differentiation.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Substrate specificity of TOR complex 2 is determined by a ubiquitin-fold domain of the Sin1 subunit

    Hisashi Tatebe et al.
    Sin1, a regulatory subunit of TOR protein kinase, has an evolutionarily conserved domain that specifically binds and recruits substrate for phosphorylation, and may represent a potential target for anti-cancer drugs.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    An unexpected role for the yeast nucleotide exchange factor Sil1 as a reductant acting on the molecular chaperone BiP

    Kevin D Siegenthaler et al.
    Building on previous work (Wang et al., 2014), it is shown that the nucleotide exchange factor of the chaperone BiP (Sil1) unexpectedly facilitates the reduction of oxidized BiP.
    1. Cell Biology

    The mammalian LINC complex component SUN1 regulates muscle regeneration by modulating drosha activity

    Tsui Han Loo et al.
    The LINC complex, that couples the interphase cytoskeleton to the nucleus, regulates the processing of a cluster of miRNAs required for muscle regeneration by recruiting and interacting directly with Drosha.
    1. Computational and Systems Biology
    2. Developmental Biology

    Systems biology derived source-sink mechanism of BMP gradient formation

    Joseph Zinski et al.
    Embryo-wide quantitative analysis of BMP signaling in zebrafish embryos, combined with a mathematical model-based computational screen, challenges the prevailing model of an antagonist counter-gradient shaping the gastrula BMP morphogen gradient and supports an antagonist sink with BMP diffusion mechanism.
    1. Cell Biology

    Cooperation between tropomyosin and α-actinin inhibits fimbrin association with actin filament networks in fission yeast

    Jenna R Christensen et al.
    The contractile ring actin binding proteins tropomyosin Cdc8 and a-actinin Ain1 synergize to effectively compete with the endocytic actin patch protein fimbrin Fim1 for associating with F-actin networks.
    1. Neuroscience

    Emergence of transformation-tolerant representations of visual objects in rat lateral extrastriate cortex

    Sina Tafazoli et al.
    Neuronal recordings from rat visual cortex reveal an object-processing pathway, along which neuronal representations become increasingly capable of supporting recognition of visual objects in spite of variation in their appearance.
    1. Biochemistry and Chemical Biology

    A surface proton antenna in carbonic anhydrase II supports lactate transport in cancer cells

    Sina Ibne Noor et al.
    Carbonic anhydrase II features a surface proton antenna that exclusively mediates proton exchange with monocarboxylate transporters to facilitate proton-coupled lactate transport in cancer cells.

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