Epigenetic scores for blood protein levels identify those at risk of multiple age-related morbidities, up to 14 years prior to onset.

A novel process by which counter-regulatory glucagon release is regulated in both mouse and human.

Pleiotropic loci that play a role in multiple neuropsychiatric diseases exist, but many of them might contribute to each disease via a distinct mechanism.

Parasite variants associated with severe malaria do not have an intrinsic growth or survival advantage in vivo, which indicates that a change in host environment is required for their selection.

Modulation of cytoplasmic lipopolysaccharide levels sensitises bacteria to polymyxin antibiotics, revealing a novel combination therapeutic approach.

Defining the probability of bacterial disease among children with severe malaria allows the integration of bacteraemia and severe malaria genome-wide association study data, identifying a novel risk locus for invasive bacterial disease.

Using fetal magnetic resonance imaging (MRI), maturational changes in tissue microstructure can be derived using diffusion MRI which provide new insight into the fundamental neurobiological transitions occurring within the emerging thalamocortical white matter pathways.

Sequencing of viral genomes could be useful for infection prevention and control within hospitals, but did not lead to a reduction in the rate of hospital-acquired SARS-CoV-2 infections over winter 2020/2021 in a large multicentre UK study.

The two most commonly used chemogenetic actuators, clozapine-N-oxide and compound 21, similarly modulate sleep in wild-type laboratory mice indicating that even designer drugs which do not convert to clozapine can elicit behavioural effects and require adequate controls.

Severe COVID-19 is characterised by a plasma proteomic biomarker signature, indicating innate immune activation, leucocyte–endothelial interactions, and epithelial injury.