Combined Inhibition of DNA replication and repair synergistically prevents tumor growth, representing a promising strategy for cancer therapy.

Precocious ribosomal DNA replication in sir2 mutants requires Fun30.

Eugenol has the ability to improve the type 1 diabetes mellitus through NRF2-mediated oxidative stress pathway.

Chemotherapy remodels lung adenocarcinoma’s tumor microenvironment by driving metabolic reprogramming and shifting immune cell functions to modulate tumor progression and immune responses.

CTFFIND5 estimates the thickness and tilt of cryogenic electron microscopy samples directly from the power spectrum of a single exposure.

SIRT1 and SIRT3-mediated immunometabolic shift governs intracellular Salmonella proliferation both in vitro and in vivo and dissemination in mice, thereby influencing the infection outcomes.

Short-term interventions, including intermittent fasting, boosting cellular energy, and promoting beneficial gut bacteria, rejuvenate osteoprogenitors in aged animals and, when combined with localized Wnt, restore youthful bone healing.