4,710 results found
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Lipid-mediated regulation of SKN-1/Nrf in response to germ cell absence

    Michael J Steinbaugh et al.
    Germ cell ablation delays C. elegans aging, in part, because unconsumed fat triggers activation of the detoxification factor SKN-1/Nrf, which is regulated by lipid signals and maintains lipid homeostasis.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    The human SKA complex drives the metaphase-anaphase cell cycle transition by recruiting protein phosphatase 1 to kinetochores

    Sushama Sivakumar et al.
    Microtubule binding by the Spindle and Kinetochore Associated (Ska) complex concentrates protein phosphatase 1 at metaphase kinetochores to overcome the spindle checkpoint thus driving anaphase onset and mitotic exit.
    1. Cell Biology
    2. Developmental Biology

    Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1

    Nicolas J Lehrbach, Gary Ruvkun
    Post-translational processing of the SKN-1A/Nrf1 transcription factor regulates proteasome expression.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Stress resets ancestral heritable small RNA responses

    Leah Houri-Zeevi et al.
    Various types of stress reset heritable small RNA responses through the function of the p38 MAPK pathway, the transcription factor SKN-1/Nrf2, and the MET-2/SETDB1 putative histone methyltransferase.
    1. Developmental Biology
    2. Genetics and Genomics

    Extensive intraspecies cryptic variation in an ancient embryonic gene regulatory network

    Yamila N Torres Cleuren et al.
    Quantitative genetic analyses reveal remarkably broad genetic variation underlies the requirement for two critical regulatory inputs into a core embryonic gene regulatory network within one animal species.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1

    Nima Etemadi et al.
    Intrinsic defects in keratinocytes can cause skin inflammation through excessive cell death and production of inflammatory molecules.
    1. Chromosomes and Gene Expression

    Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice

    Liou Y Sun et al.
    Mice with a mutation that disrupts the release of growth hormone show greatly increased lifespan, which can be further increased by caloric restriction.
    1. Computational and Systems Biology
    2. Developmental Biology

    A multi-scale model for hair follicles reveals heterogeneous domains driving rapid spatiotemporal hair growth patterning

    Qixuan Wang et al.
    Regional differences in activator and inhibitor signals alter hair cycle pace across mouse skin and produce unique fur renewal 'landscapes', with fastest renewal on the ventrum and slowest renewal on the ear pinnae.
    1. Cell Biology

    Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans

    Yanan Sun et al.
    Cell biological and genetic studies reveal age-associated alterations of lysosomes and modulation of lysosomal activity by longevity pathways.
    1. Neuroscience

    Shank is a dose-dependent regulator of Cav1 calcium current and CREB target expression

    Edward Pym et al.
    Changes in Shank gene dosage alter voltage-activated calcium current and calcium-activated gene expression in a manner that parallels the effects of human Shank copy number variation on psychiatric disease risk.

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