264 results found
    1. Immunology and Inflammation

    Tuning of in vivo cognate B-T cell interactions by Intersectin 2 is required for effective anti-viral B cell immunity

    Marianne Burbage et al.
    Intersectin2 deficiency is associated with impaired humoral responses to viral infection and B-cell-intrisic defects in germinal centre formation, resulting from the reduced ability of intersectin2-KO B cells to establish cognate interactions with helper T cells.
    1. Cell Biology
    2. Computational and Systems Biology

    Science Forum: The Human Cell Atlas

    Aviv Regev et al.
    Advances in techniques for analysing single cells and tissues have inspired an international effort to create comprehensive reference maps of all human cells - the fundamental units of life - as a basis for both understanding human health and diagnosing, monitoring and treating disease.
    1. Developmental Biology and Stem Cells

    Tissue-specific regulation of BMP signaling by Drosophila N-glycanase 1

    Antonio Galeone et al.
    N-glycanase 1 is required for a BMP autoregulatory loop in the visceral mesoderm and for intestinal development in Drosophila.
    1. Cell Biology

    Recruitment dynamics of ESCRT-III and Vps4 to endosomes and implications for reverse membrane budding

    Manuel Alonso Y Adell et al.
    Quantitative 3D lattice light sheet microscopy of unperturbed cells combined with electron tomography and acute loss of function experiments reveals how dynamic ESCRT-III/Vps4 assemblies succeed in reverse membrane budding on endosomes.
    1. Developmental Biology and Stem Cells

    Lunatic fringe-mediated Notch signaling regulates adult hippocampal neural stem cell maintenance

    Fatih Semerci et al.
    In adult mouse hippocampus, neural stem cell and their progeny communicate via Lunatic Fringe mediated Notch signaling to regulate stem cell quiescence, division, and fate.
    1. Developmental Biology and Stem Cells
    2. Human Biology and Medicine

    Human embryonic lung epithelial tips are multipotent progenitors that can be expanded in vitro as long-term self-renewing organoids

    Marko Z Nikolić et al.
    Improved characterisation of human embryonic lung development highlights human-mouse differences and facilitates the development of defined culture conditions for the expansion of self-renewing, multipotent human lung epithelial progenitor cells.
    1. Computational and Systems Biology
    2. Neuroscience

    Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-regulated switch in protein phosphatase 2A inhibition

    Veronica Musante et al.
    A complex interplay between MAST3 and PKA protein kinases and the regulatory protein ARPP-16 allows cAMP to control the activity of protein phosphatase 2A.
    1. Chromosomes and Gene Expression
    2. Human Biology and Medicine

    Transcriptional networks specifying homeostatic and inflammatory programs of gene expression in human aortic endothelial cells

    Nicholas T Hogan et al.
    An integrative genome-wide approach supports a direct and collaborative role of ETS and AP-1 transcription factors in maintaining endothelial cell-specific and anti-inflammatory gene expression programs.
    1. Cell Biology

    Spatiotemporal regulation of autophagy during Caenorhabditis elegans aging

    Jessica T Chang et al.
    Autophagic flux assays in the nematode Caenorhabditis elegans suggest that autophagy decreases during normal aging, whereas long-lived daf-2 and glp-1 mutants maintain autophagic capacity in distinct spatiotemporal-specific manners to extend lifespan.
    1. Cancer Biology

    NFATc2 enhances tumor-initiating phenotypes through the NFATc2/SOX2/ALDH axis in lung adenocarcinoma

    Zhi-Jie Xiao et al.
    NFATc2 maintains the drug-induced TIC phenotypes through trans-activating SOX2/ALDH1A1 expression and scavenging stress from ROS.

Refine your results by:

Type
Research categories