317 results found
    1. Chromosomes and Gene Expression

    Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss

    Meritxell Espino Guarch et al.
    SLC7A8 a neutral amino acid transporter has a key role in the maintenance of hearing during aging and its absence causes early onset of hearing loss.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structures of the human glutamine transporter SLC1A5 (ASCT2) in the outward-facing conformation

    Xiaodi Yu et al.
    Cryo-EM structures of unliganded SLC1A5 and its complex with glutamine in outward-facing state provide insights into the substrate specificity and transport mechanism and will be helpful for developing selective inhibitors.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Control of Slc7a5 sensitivity by the voltage-sensing domain of Kv1 channels

    Shawn M Lamothe et al.
    The voltage-sensing mechanism of a subfamily of potassium channels is modulated in unconventional ways by an amino acid transporter.
    1. Cell Biology

    The copy-number and varied strengths of MELT motifs in Spc105 balance the strength and responsiveness of the spindle assembly checkpoint

    Babhrubahan Roy et al.
    Cell biological and genetic analyses reveal how budding yeast cells optimize Spindle Assembly checkpoint signaling to maximize chromosome segregation accuracy and minimize unnecessary delays in anaphase onset.
    1. Immunology and Inflammation

    Quantitative analysis of how Myc controls T cell proteomes and metabolic pathways during T cell activation

    Julia M Marchingo et al.
    Myc-dependent induction of amino acid transporter expression in response to T cell receptor activation is essential to enable T cell proteome remodelling upon immune activation.
    1. Immunology and Inflammation

    Critical role of WNK1 in MYC-dependent early mouse thymocyte development

    Robert Köchl et al.
    Development of mouse thymocytes through the pre-TCR checkpoint requires WNK1 kinase signalling via the OXSR1 and STK39 kinases and the SLC12A2 ion co-transporter leading to MYC-dependent cell proliferation.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mechanistic basis of the inhibition of SLC11/NRAMP-mediated metal ion transport by bis-isothiourea substituted compounds

    Cristina Manatschal et al.
    The structural and mechanistic characterization of competitive inhibition of human DMT1 offers a promising route for the development of compounds for the treatment of iron overload disorders.
    1. Neuroscience

    Estrogenic-dependent glutamatergic neurotransmission from kisspeptin neurons governs feeding circuits in females

    Jian Qiu et al.
    Estrogen increases hypothalamic arcuate kisspeptin neuronal excitability and glutamate release to coordinate autonomic functions for maximizing reproductive success.
    1. Neuroscience

    Proteome profile of peripheral myelin in healthy mice and in a neuropathy model

    Sophie B Siems et al.
    A comprehensive compendium of myelin proteins in the peripheral nervous system has been created, alongside a method to address molecular diversity of myelin sheaths in health and disease.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Optimization-by-design of hepatotropic lipid nanoparticles targeting the sodium-taurocholate cotransporting polypeptide

    Dominik Witzigmann et al.
    The combination of in vitro investigations, the zebrafish screening model and rodent experiments offered a unique approach to optimizing nanoparticles modified with Hepatitis B virus-derived peptides to specifically target hepatocytes.

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