6,885 results found
    1. Microbiology and Infectious Disease

    Fitness advantage of Bacteroides thetaiotaomicron capsular polysaccharide in the mouse gut depends on the resident microbiota

    Daniel Hoces, Giorgia Greter ... Emma Slack
    Neutral tagging and detailed analysis of bacterial growth kinetics can quantify the mechanisms of colonization resistance in differently colonized animals.
    1. Structural Biology and Molecular Biophysics

    Sequence co-evolution gives 3D contacts and structures of protein complexes

    Thomas A Hopf, Charlotta P I Schärfe ... Debora S Marks
    Interactions in protein complexes can be predicted from evolutionary information from genomic sequences.
    1. Developmental Biology

    Marcks and Marcks-like 1 proteins promote spinal cord development and regeneration in Xenopus

    Mohamed El Amri, Abhay Pandit, Gerhard Schlosser
    Marcks and Marcks-like 1 proteins are required for normal neurite formation and proliferation of neuro-glial progenitors during development and regeneration of the Xenopus spinal cord implicating these proteins as critical new factors for spinal cord development and regeneration.
    1. Evolutionary Biology
    2. Neuroscience

    A cerebellar substrate for cognition evolved multiple times independently in mammals

    Jeroen B Smaers, Alan H Turner ... Chet C Sherwood
    Multiple independent directional selection events on a neural substrate that underpins domain-general associative abilities partly explains independent occurrences of complex behavior in different lineages of mammals.
    1. Neuroscience

    Flexible and efficient simulation-based inference for models of decision-making

    Jan Boelts, Jan-Matthis Lueckmann ... Jakob H Macke
    A new machine learning method makes it possible to efficiently identify the parameters of cognitive models using Bayesian inference, even when only model simulations are available.
    1. Cell Biology

    Golgi localized β1-adrenergic receptors stimulate Golgi PI4P hydrolysis by PLCε to regulate cardiac hypertrophy

    Craig A Nash, Wenhui Wei ... Alan V Smrcka
    β-adrenergic receptors at the Golgi apparatus activate a local signaling pathway, not accessed by cell surface receptors, to drive cardiac hypertrophy and could represent a target for heart failure therapy.
    1. Computational and Systems Biology
    2. Neuroscience

    Training deep neural density estimators to identify mechanistic models of neural dynamics

    Pedro J Gonçalves, Jan-Matthis Lueckmann ... Jakob H Macke
    Deep neural networks can be trained to automatically find mechanistic models which quantitatively agree with experimental data, providing new opportunities for building and visualizing interpretable models of neural dynamics.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Stress conditions promote Leishmania hybridization in vitro marked by expression of the ancestral gamete fusogen HAP2 as revealed by single-cell RNA-seq

    Isabelle Louradour, Tiago Rodrigues Ferreira ... David Sacks
    Following exposure of Leishmania culture promastigotes to DNA stress, single-cell RNA sequencing reveals discrete clusters of cells associated with efficient generation of hybrids between different species and strains in vitro marked by expression of the ancestral gamete fusogen HAP2.
    1. Immunology and Inflammation
    2. Neuroscience

    Circulating myeloid cells invade the central nervous system to mediate cachexia during pancreatic cancer

    Kevin G Burfeind, Xinxia Zhu ... Daniel L Marks
    Circulating myeloid cells invade the brain during pancreatic cancer, where they accumulate at a unique central nervous system interface and drive anorexia and muscle catabolism.
    1. Cell Biology
    2. Developmental Biology

    Cell volume changes contribute to epithelial morphogenesis in zebrafish Kupffer’s vesicle

    Agnik Dasgupta, Matthias Merkel ... Jeffrey D Amack
    During Kupffer's vesicle morphogenesis, cell volume anisotropy impacts cell shape changes.

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