87 results found
    1. Developmental Biology

    End-of-life targeted degradation of DAF-2 insulin/IGF-1 receptor promotes longevity free from growth-related pathologies

    Richard Venz et al.
    Inducible degradation of the insulin/insulin-like growth factor-1 receptor shows that a doubling in lifespan is possible even at extremely old ages in an organism.
    1. Developmental Biology

    Development and genetics of red coloration in the zebrafish relative Danio albolineatus

    Delai Huang et al.
    In the zebrafish relative Danio albolineatus, red erythrophores share a common progenitor with yellow xanthophores and require Cyp2ae2 and Bdh1a for accumulation of red ketocarotenoid pigment.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    In vivo analysis reveals that ATP-hydrolysis couples remodeling to SWI/SNF release from chromatin

    Ben C Tilly et al.
    Visualization of BRM remodelers engaging their endogenous genomic targets revealed highly transient and dynamic interactions with chromatin, which are fueled by ATP-hydrolysis.
    1. Cancer Biology

    An epigenetic switch regulates the ontogeny of AXL-positive/EGFR-TKi-resistant cells by modulating miR-335 expression

    Polona Safaric Tepes et al.
    Erlotinib-resistant AXL overexpressing cells are present in therapy-naive tumors, and expression of AXL in these cells is regulated through a stochastic mechanism centered on the epigenetic regulation of miR-335.
    1. Cell Biology

    Single-cell transcriptomics defines heterogeneity of epicardial cells and fibroblasts within the infarcted murine heart

    Julia Hesse et al.
    The transcriptional landscape of epicardial cells revealed 11 cell populations that differentially expressed early cardiac genes and numerous cardioprotective paracrine factors defining their regenerative potential.
    1. Genetics and Genomics
    2. Medicine

    Genetic architecture of 11 organ traits derived from abdominal MRI using deep learning

    Yi Liu et al.
    Systematic quantification of abdominal organ health parameters using deep learning generates new insights into the genetic architecture of cardiometabolic health traits.
    1. Cell Biology
    2. Developmental Biology

    Single-cell transcriptome analysis defines heterogeneity of the murine pancreatic ductal tree

    Audrey M Hendley et al.
    Single-cell RNA-sequencing analyses and functional studies define heterogeneity within the pancreatic ductal tree and unique properties of subpopulations of duct cells including an epithelial-mesenchymal transcriptomic axis and roles in chronic pancreatic inflammation.
    1. Genetics and Genomics
    2. Medicine

    A Mendelian randomization study of the role of lipoprotein subfractions in coronary artery disease

    Qingyuan Zhao et al.
    High-density lipoprotein (HDL) subfraction traits appear to have heterogeneous effects on coronary artery disease, giving support to the HDL function hypothesis.
    1. Biochemistry and Chemical Biology

    De novo macrocyclic peptides dissect energy coupling of a heterodimeric ABC transporter by multimode allosteric inhibition

    Erich Stefan et al.
    By random nonstandard peptide integrated discovery, combinatorial macrocyclic peptides were leavaged that target a heterodimeric ABC transport complex and explore fundamental principles of the substrate translocation cycle.
    1. Cell Biology

    SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation

    David W Sanders et al.
    A high-throughput microscopy screen for drugs that modulate SARS-CoV-2 spike-mediated membrane fusion identifies an essential role for cholesterol in both virus entry and syncytia formation.

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