995 results found
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    A unifying mechanism for the biogenesis of membrane proteins co-operatively integrated by the Sec and Tat pathways

    Fiona J Tooke et al.
    Bioinformatics and experimental approaches identify families of membrane proteins requiring the co-ordinated action of the Sec pathway and Tat pathways for their integration and define features of the polypeptides that mediate interaction with these pathways.
    1. Cell Biology

    dPob/EMC is essential for biosynthesis of rhodopsin and other multi-pass membrane proteins in Drosophila photoreceptors

    Takunori Satoh et al.
    A membrane protein complex in the endoplasmic reticulum is a key factor for the biogenesis of multi-pass transmembrane proteins, including Rh1, and its loss causes retinal degeneration.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural basis for the recognition of spliceosomal SmN/B/B’ proteins by the RBM5 OCRE domain in splicing regulation

    André Mourão et al.
    Interactions with Sm proteins can provide a way in which regulatory factors can modulate alternative splice site choices.
    1. Genes and Chromosomes

    MukB ATPases are regulated independently by the N- and C-terminal domains of MukF kleisin

    Katarzyna Zawadzka et al.
    In Escherichia coli structural maintenance of chromosomes (SMC) complex, MukBEF, a dimeric MukF kleisin binds and activates MukB SMC ATPases through two independent interfaces provided by distinct MukF N- and C-terminal domains.
    1. Structural Biology and Molecular Biophysics
    2. Genes and Chromosomes

    The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat

    Ursula Schulze-Gahmen et al.
    Structure-function analysis of the super elongation complex formed when HIV replicates inside cells reveals that the HIV-1 Tat protein binds to a cleft between P-TEFb, an enzyme that is involved in normal transcription, and AFF4, a protein that is used to build the super elongation complex
    1. Biochemistry and Chemical Biology
    2. Genes and Chromosomes

    SMC condensin entraps chromosomal DNA by an ATP hydrolysis dependent loading mechanism in Bacillus subtilis

    Larissa Wilhelm et al.
    The Smc–ScpAB complex-a prokaryotic ancestor of cohesin, condensin and Smc5/6-loads onto the bacterial chromosome by employing ATP hydrolysis to capture DNA fibers within its tripartite ring.
    1. Neuroscience

    Decreased microRNA levels lead to deleterious increases in neuronal M2 muscarinic receptors in Spinal Muscular Atrophy models

    Patrick J O'Hern et al.
    In invertebrate and vertebrate models of Spinal Muscular Atrophy, diminished SMN protein causes Gemin3-dependent decreases in microRNA function, leading to upregulated M2 muscarinic receptor and deleterious consequences.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology and Stem Cells

    Tumor Angiogenesis: Taking aim at Sox18

    Injune Kim, Gou Young Koh
    A small molecule called Sm4 can disrupt interactions involving a transcription factor called Sox18, while having little impact on other members of the SoxF family.
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