3 results found
    1. Cell Biology

    Differential axonal trafficking of Neuropeptide Y-, LAMP1-, and RAB7-tagged organelles in vivo

    Joris P Nassal, Fiona H Murphy ... Matthijs Verhage
    In vivo live imaging reveals the trafficking dynamics of three cellular organelles in neocortical axons with single vesicle resolution and demonstrates activity-dependent changes.
    1. Cell Biology
    2. Neuroscience

    SNAP25 disease mutations change the energy landscape for synaptic exocytosis due to aberrant SNARE interactions

    Anna Kádková, Jacqueline Murach ... Jakob Balslev Sørensen
    SNAP25 disease mutations within the synaptotagmin interface impair vesicle priming and cause uncontrolled spontaneous release due to enhanced SNARE:SNARE interactions, whereas a mutation within the SNARE-bundle increases the fusion energy barrier.
    1. Neuroscience

    Rab10 regulates neuropeptide release by maintaining Ca2+ homeostasis and protein synthesis

    Jian Dong, Miao Chen ... Matthijs Verhage
    Revised
    Reviewed Preprint v2
    Updated

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