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    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Munc18-1 catalyzes neuronal SNARE assembly by templating SNARE association

    Junyi Jiao et al.
    Sec1/Munc18-family proteins chaperone SNARE assembly via a common templating mechanism.
    1. Neuroscience

    Large-scale two-photon imaging revealed super-sparse population codes in the V1 superficial layer of awake monkeys

    Shiming Tang et al.
    Two-photon imaging reveals super-sparse responses to natural images in primate V1, which carry sufficient information for discrimination of the input natural images with high accuracy.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Common intermediates and kinetics, but different energetics, in the assembly of SNARE proteins

    Sylvain Zorman et al.
    The energy landscape of SNARE folding and assembly is optimized for efficient stage-wise membrane fusion.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    SM proteins Sly1 and Vps33 co-assemble with Sec17 and SNARE complexes to oppose SNARE disassembly by Sec18

    Braden T Lobingier et al.
    Sec1/Munc18 (SM) proteins shield SNARE complexes from NSF/Sec18-mediated disassembly through cooperative binding interactions with SNARE complexes and the universal co-chaperone α-SNAP/Sec17.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Structural principles of SNARE complex recognition by the AAA+ protein NSF

    K Ian White et al.
    Electron-cryomicroscopy structures of the supercomplex of NSF, αSNAP, and neuronal SNAREs in the presence of ATP under non-hydrolyzing conditions at 3.9 Å resolution reveal interactions between the N-terminal residues of SNAP-25 and NSF.
    1. Neuroscience

    A synaptotagmin suppressor screen indicates SNARE binding controls the timing and Ca2+ cooperativity of vesicle fusion

    Zhuo Guan et al.
    A suppressor screen of dominant-negative synaptotagmin-induced lethality in Drosophila identifies key properties of the protein that regulate fusion, including the SNARE interaction surface.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Reconciling isothermal titration calorimetry analyses of interactions between complexin and truncated SNARE complexes

    Eric A Prinslow et al.
    Isothermal titration calorimetry experiments clarify apparently discrepant results described previously and show that N-terminal sequences of complexin bind to SNARE complexes containing C-terminally truncated synaptobrevin when they include the syntaxin-1 juxtamembrane region.
    1. Developmental Biology
    2. Neuroscience

    Morphologic diversity of cutaneous sensory afferents revealed by genetically directed sparse labeling

    Hao Wu et al.
    The first survey of the complete morphologies of nerve endings in the skin of mice has revealed enormous structural diversity.
    1. Biochemistry and Chemical Biology

    Membranes linked by trans-SNARE complexes require lipids prone to non-bilayer structure for progression to fusion

    Michael Zick et al.
    Lipids with a propensity to form nonbilayer structures must be present for the last step of membrane fusion to take place.
  1. Philosophy of Biology: Understanding regeneration at different scales

    Kate MacCord, Jane Maienschein
    To understand how regeneration works across the different scales of living systems, we first need to identify the essential components underlying this process.