A post-translational modification called O-GlcNAcylation modulates the activity of the SOX2 transcription factor in pluripotent stem cells.

The vertebrate testis-determining gene, Sox9, also controls adult testis maintenance in mammals, acting redundantly with its paralog Sox8.

Lattice light-sheet single-molecule imaging shows 3D Sox2 enhancer clusters in live embryonic stem cells and reveals a model linking 3D spatial distribution of cis-elements, differential target search features and localized gene regulation.

Establishment of the acinar lineage in the salivary gland requires SOX2 and parasympathetic nerves.

NFATc2 maintains the drug-induced TIC phenotypes through trans-activating SOX2/ALDH1A1 expression and scavenging stress from ROS.

The LATS/YAP/TAZ cascade promotes SOX2+ pituitary stem cell fate and when over-activated, transforms normal stem cells into cancer stem cells.

SOX2 causes resistance to anti-EGFR therapies in EGFR-mutant lung cancer.

Sox8 can induce female-to-male sex reversal of the R-spondin1 loss-of-function mouse mutants in the absence of Sox9..

Transcription factor Sox9 has an important role in neocortex expansion, where its expression in basal progenitors increases proliferation, induces premature gliogenesis and promotes the expression of extracellular matrix components.

Sox2 transcription is not correlated with spatial proximity of its essential regulatory enhancer in embryonic stem cells, suggesting gene transcription is not limited to periods of direct enhancer-promoter contact.