NFATc2 maintains the drug-induced TIC phenotypes through trans-activating SOX2/ALDH1A1 expression and scavenging stress from ROS.

Establishment of the acinar lineage in the salivary gland requires SOX2 and parasympathetic nerves.

SOX2 causes resistance to anti-EGFR therapies in EGFR-mutant lung cancer.

A set of ex vivo and in vivo experiments, including genetic ablation and regeneration studies, identify a key regulatory function of SOXF factors in muscle stem cells in mice.

The vertebrate testis-determining gene, Sox9, also controls adult testis maintenance in mammals, acting redundantly with its paralog Sox8.

A post-translational modification called O-GlcNAcylation modulates the activity of the SOX2 transcription factor in pluripotent stem cells.

Neural retina-derived retinoic acids synthesized by Aldh1a1 control choroidal vascular development by regulating RPE-secreted VEGF.

Sox21b-1 regulates simultaneous formation of anterior segments and addition of posterior segments in a spider, which resembles segmentation in long- and short-germ insects, and suggests SoxB regulation of segmentation is an ancestral feature of arthropods.

Lattice light-sheet single-molecule imaging shows 3D Sox2 enhancer clusters in live embryonic stem cells and reveals a model linking 3D spatial distribution of cis-elements, differential target search features and localized gene regulation.

Biochemical analyses show that mitochondrial COX16 assists in the process of copper insertion into COX2 and reveal a second COX16 function in linking assembly routes of the redox center-containing COX1 and COX2 subunits.