Genetic manipulations show that endogenous transcription factors of the SoxB1 class act redundantly to maintain primed pluripotency and reveal differential effects on transitions between pluripotent and differentiation states.

The balance between SOX2 and SOX21 is evolutionary conserved and is important for cell fate decision during lung epithelium development and repair after damage.

A post-translational modification called O-GlcNAcylation modulates the activity of the SOX2 transcription factor in pluripotent stem cells.

A newly discovered feedback amplification loop between stem cells and their immediate daughter progenitor cells drives epithelial regeneration and tumor development.

SOX11+ breast tumours display reactivated embryonic developmental signalling and organogenetic features and are at elevated risk of developing metastases, so may benefit from more aggressive therapies.

Lattice light-sheet single-molecule imaging shows 3D Sox2 enhancer clusters in live embryonic stem cells and reveals a model linking 3D spatial distribution of cis-elements, differential target search features and localized gene regulation.

Sox2 transcription is not correlated with spatial proximity of its essential regulatory enhancer in embryonic stem cells, suggesting gene transcription is not limited to periods of direct enhancer-promoter contact.

Establishment of the acinar lineage in the salivary gland requires SOX2 and parasympathetic nerves.

Spatial variations of transcription factor expression regulate the choice of progenitors to stay in their niche or to migrate into neural and mesodermal tissues.

The LATS/YAP/TAZ cascade promotes SOX2+ pituitary stem cell fate and when over-activated, transforms normal stem cells into cancer stem cells.