BRD9 provides the first actionable therapeutic target in synovial sarcoma tumours that is both biochemically and functionally linked to the SS18-SSX fusion protein which drives disease development.

Genomes take advantage of the gene-duplicating ability of retroelements to birth novel innate immune defense genes.

The completion of neural tube closure requires small GTPase-regulated membrane protrusions from non-neural ectoderm cells at the tips of the neural folds.

Yeast cells can be engineered to study starch, the semi-crystalline storage carbohydrate from plants that is central to human nutrition.

The genome of a tiny tomato pest reveals mechanisms that underlie metazoan genome reduction.

Inhibition of the integrated stress response restores neuronal and immune dysfunction and alleviates memory deficits in aged mice.

Genetic and biochemical analysis reveal a variant in HSF2BP causing POI and C19ORF57/BRME1 as an interactor and stabilizer of HSF2BP by forming a complex with BRCA2, RAD51, RPA and PALB2.

There is no relationship between the demographic susceptibility to extinction and the estimated extinction chronology among Sahul’s megafauna, suggesting that human choices, a species’ ecological requirements, and/or random climate variation instead determined the extinction chronology.

Maternal positional information in the fly embryo can be read rapidly in spite of the gene-expression bottleneck and general examples of regulatory architectures that combine speed and accuracy are provided.

A new intricate reciprocity between microbiology and physics results in collective protection from desiccation through differential formation of stable microdroplets around bacterial aggregates on surfaces drying under moderate humidity.