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Small molecule cognitive enhancer reverses age-related memory decline in mice
Karen Krukowski et al.
Inhibition of the integrated stress response restores neuronal and immune dysfunction and alleviates memory deficits in aged mice.
Burst mitofusin activation reverses neuromuscular dysfunction in murine CMT2A
Antonietta Franco et al.
A trial of mitofusin activation shows neuron regeneration and phenotype reversal in vitro and in vivo in experimental Charcot–Marie–Tooth disease type 2A caused by mitofusin 2 mutations.
Microbiology and Infectious Disease
Dynamically evolving novel overlapping gene as a factor in the SARS-CoV-2 pandemic
Chase W Nelson et al.
A novel, overlapping, putatively functional gene in SARS-CoV-2,
, is absent from close relatives of SARS-CoV-2 and may have contributed to the biology, emergence, or spread of the virus.
meiotic driver utilizes controlled protein aggregation to generate selective cell death
Nicole L Nuckolls et al.
The Wtf4 antidote protein assembles with the Wtf4 poison protein and promotes the transportation of the assembled proteins to the vacuole for sequestration or destruction.
PLK-1 promotes the merger of the parental genome into a single nucleus by triggering lamina disassembly
Griselda Velez-Aguilera et al.
The polo-like kinase (Plk1) phophorylates the
lamin LMN-1 to promote timely lamina disassembly, which is essential for the merging of the parental chromosomes at the beginning of life.
Collagen-rich omentum is a premetastatic niche for integrin α2-mediated peritoneal metastasis
Yen-Lin Huang et al.
Inhibition of ITGA2-mediated cancer cell-collagen interaction or targeting focal adhesion kinase activity may present an opportunity for therapeutic intervention of metastatic spread in ovarian cancer.
Computational and Systems Biology
Inherent regulatory asymmetry emanating from network architecture in a prevalent autoregulatory motif
Md Zulfikar Ali et al.
Network architecture and physiological features of the cell dictate asymmetric gene regulation between a negative autoregulatory TF gene and its target gene.
A missense in HSF2BP causing primary ovarian insufficiency affects meiotic recombination by its novel interactor C19ORF57/BRME1
Natalia Felipe-Medina et al.
Genetic and biochemical analysis reveal a variant in HSF2BP causing POI and C19ORF57/BRME1 as an interactor and stabilizer of HSF2BP by forming a complex with BRCA2, RAD51, RPA and PALB2.
Physics of Living Systems
Efficient coding of natural scene statistics predicts discrimination thresholds for grayscale textures
Tiberiu Tesileanu et al.
An optimization principle allows natural-image data to predict human sensitivity to synthetic, un-natural textures with multiple gray levels.
Epidemiology and Global Health
Reducing respiratory syncytial virus (RSV) hospitalization in a lower-income country by vaccinating mothers-to-be and their households
Samuel PC Brand et al.
Targeting the mothers, and other household members, of newborns with a mixture of respiratory syncytial virus (RSV) vaccines is both efficient and effective at reducing RSV hospitalizations.
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