2,466 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Wss1 metalloprotease partners with Cdc48/Doa1 in processing genotoxic SUMO conjugates

    Maxim Y Balakirev et al.
    Wss1 is both a metalloprotease and SUMO ligase found in association with Cdc48 and Doa1 and accumulating in the vacuole upon DNA damage.
    1. Neuroscience

    Analysis of SUMO1-conjugation at synapses

    James A Daniel et al.
    Analyses using His6-HA-SUMO1 and SUMO1 KO mice indicate that SUMO1 modification of synaptic proteins is either absent or cannot be detected in brain and cultured neurons.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Defective RNA polymerase III is negatively regulated by the SUMO-Ubiquitin-Cdc48 pathway

    Zheng Wang et al.
    The SUMO-Ub-Cdc48 pathway is a novel regulatory mechanism of Pol III and a potential therapeutic target for Pol III-related human diseases.
    1. Structural Biology and Molecular Biophysics

    Allosteric activation of SENP1 by SUMO1 β-grasp domain involves a dock-and-coalesce mechanism

    Jingjing Guo, Huan-Xiang Zhou
    Simulations of molecular dynamics suggest how the binding of the β-grasp domain of SUMO1 induces conformational and dynamic effects to activate SENP1.
    1. Biochemistry and Chemical Biology

    Characterisation of the biflavonoid hinokiflavone as a pre-mRNA splicing modulator that inhibits SENP

    Andrea Pawellek et al.
    Hinokiflavone is identified as a splicing modulator that blocks progression from spliceosome complex A to complex B and inhibits SUMO protease SENP1, causing hyper-SUMOylation affecting 6 U2 snRNP proteins.
    1. Developmental Biology

    Patched1 and Patched2 inhibit Smoothened non-cell autonomously

    Brock Roberts et al.
    Ptch1/2 can lower the sensitivity of Smo to activation by Shh via the secretion of a sterol precursor.
    1. Neuroscience

    Supramammillary nucleus synchronizes with dentate gyrus to regulate spatial memory retrieval through glutamate release

    Yadong Li et al.
    Multi-fiber photometry recording and circuit-based manipulation in vivo identify a long-range SuM-DG circuit linking two highly correlated subcortical regions to regulate spatial memory retrieval through SuM glutamate transmission.
    1. Human Biology and Medicine
    2. Neuroscience

    SUMOylation of NaV1.2 channels mediates the early response to acute hypoxia in central neurons

    Leigh D Plant et al.
    The immediate response of the brain to a sudden, harmful drop in oxygen supply is the addition of SUMO proteins to sodium ion channels in neurons, increasing their activity.
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    Pyrophosphate modulates plant stress responses via SUMOylation

    M Görkem Patir-Nebioglu et al.
    In vivo inhibition of SUMO activating E1-enzymes by pyrophosphate reveals a mode of integrating metabolism and stress tolerance that is conserved across kingdoms.
    1. Cell Biology
    2. Human Biology and Medicine

    A gene-expression screen identifies a non-toxic sumoylation inhibitor that mimics SUMO-less human LRH-1 in liver

    Miyuki Suzawa et al.
    The FDA-approved compound and plant extract tannic acid is a non-toxic chemical tool for modulating sumoylation in multiple platforms.

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