63 results found
    1. Cell Biology
    2. Human Biology and Medicine

    A gene-expression screen identifies a non-toxic sumoylation inhibitor that mimics SUMO-less human LRH-1 in liver

    Miyuki Suzawa et al.
    The FDA-approved compound and plant extract tannic acid is a non-toxic chemical tool for modulating sumoylation in multiple platforms.
    1. Cell Biology
    2. Neuroscience

    The insulin/IGF signaling cascade modulates SUMOylation to regulate aging and proteostasis in Caenorhabditis elegans

    Lorna Moll et al.
    By controlling the SUMOylation of the protein CAR-1, the aging-regulating pathways downstream of the Insulin/IGF signaling cascade and of the germ cells of the nematode Caenorhabditis elegans are integrated.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Shigella entry unveils a calcium/calpain-dependent mechanism for inhibiting sumoylation

    Pierre Lapaquette et al.
    Shigella infection induces a calpain-mediated loss of SUMO conjugates that promotes bacterial entry.
    1. Microbiology and Infectious Disease

    TRIM28 promotes HIV-1 latency by SUMOylating CDK9 and inhibiting P-TEFb

    Xiancai Ma et al.
    TRIM28 was found to be a versatile dual-function latency contributor by bridging both suppressive epigenetic modifications and RNAP II transcriptional-pausing, and can be a novel target to develop latency-reversing agents.
    1. Cell Biology

    Sumoylation promotes optimal APC/C activation and timely anaphase

    Christine C Lee et al.
    The Anaphase Promoting Complex/Cyclosome is regulated by sumoylation to ensure timely mitotic exit in human cells.
    1. Cell Biology

    SUMO peptidase ULP-4 regulates mitochondrial UPR-mediated innate immunity and lifespan extension

    Kaiyu Gao et al.
    SUMOylation regulates mitochondrial UPR signaling through modulation of transcription factors DVE-1 and ATFS-1.
    1. Human Biology and Medicine
    2. Neuroscience

    SUMOylation of NaV1.2 channels mediates the early response to acute hypoxia in central neurons

    Leigh D Plant et al.
    The immediate response of the brain to a sudden, harmful drop in oxygen supply is the addition of SUMO proteins to sodium ion channels in neurons, increasing their activity.
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    Pyrophosphate modulates plant stress responses via SUMOylation

    M Görkem Patir-Nebioglu et al.
    In vivo inhibition of SUMO activating E1-enzymes by pyrophosphate reveals a mode of integrating metabolism and stress tolerance that is conserved across kingdoms.
    1. Neuroscience

    Analysis of SUMO1-conjugation at synapses

    James A Daniel et al.
    Analyses using His6-HA-SUMO1 and SUMO1 KO mice indicate that SUMO1 modification of synaptic proteins is either absent or cannot be detected in brain and cultured neurons.

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