93 results found
    1. Cell Biology
    2. Neuroscience

    The insulin/IGF signaling cascade modulates SUMOylation to regulate aging and proteostasis in Caenorhabditis elegans

    Lorna Moll et al.
    By controlling the SUMOylation of the protein CAR-1, the aging-regulating pathways downstream of the Insulin/IGF signaling cascade and of the germ cells of the nematode Caenorhabditis elegans are integrated.
    1. Cell Biology

    A gene-expression screen identifies a non-toxic sumoylation inhibitor that mimics SUMO-less human LRH-1 in liver

    Miyuki Suzawa et al.
    The FDA-approved compound and plant extract tannic acid is a non-toxic chemical tool for modulating sumoylation in multiple platforms.
    1. Microbiology and Infectious Disease

    TRIM28 promotes HIV-1 latency by SUMOylating CDK9 and inhibiting P-TEFb

    Xiancai Ma et al.
    TRIM28 was found to be a versatile dual-function latency contributor by bridging both suppressive epigenetic modifications and RNAP II transcriptional-pausing, and can be a novel target to develop latency-reversing agents.
    1. Developmental Biology

    HDAC1 SUMOylation promotes Argonaute-directed transcriptional silencing in C. elegans

    Heesun Kim et al.
    HDAC SUMOylation promotes the association of other chromatin remodeling factors with the nuclear Argonaute WAGO-9, which is required for de novo heterochromatin silencing.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Shigella entry unveils a calcium/calpain-dependent mechanism for inhibiting sumoylation

    Pierre Lapaquette et al.
    Shigella infection induces a calpain-mediated loss of SUMO conjugates that promotes bacterial entry.
    1. Plant Biology

    SUMOylation contributes to proteostasis of the chloroplast protein import receptor TOC159 during early development

    Sonia Accossato et al.
    SUMOylation contributes to the fine-tuning of the proteostatic equilibrium of essential chloroplast protein import receptor TOC159 at early plant development.
    1. Neuroscience

    SUMOylation of NaV1.2 channels mediates the early response to acute hypoxia in central neurons

    Leigh D Plant et al.
    The immediate response of the brain to a sudden, harmful drop in oxygen supply is the addition of SUMO proteins to sodium ion channels in neurons, increasing their activity.
    1. Cell Biology

    Sumoylation promotes optimal APC/C activation and timely anaphase

    Christine C Lee et al.
    The Anaphase Promoting Complex/Cyclosome is regulated by sumoylation to ensure timely mitotic exit in human cells.
    1. Cell Biology

    SUMO peptidase ULP-4 regulates mitochondrial UPR-mediated innate immunity and lifespan extension

    Kaiyu Gao et al.
    SUMOylation regulates mitochondrial UPR signaling through modulation of transcription factors DVE-1 and ATFS-1.
    1. Genetics and Genomics

    PIE-1 SUMOylation promotes germline fates and piRNA-dependent silencing in C. elegans

    Heesun Kim et al.
    PIE-1 engages SUMO to preserve the embryonic germline fate and also to promote the assembly of a MEP-1/Mi-2/HDA-1 chromatin remodeling complex required for inherited Argonaute-mediated gene silencing in the adult hermaphrodite germline.

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