Inactivation of SURF4 leads to impaired secretion of PCSK9 and apolipoproteins resulting in low plasma cholesterol without detrimental consequences to the liver.

A CRISPR-based genomic screen identifies the ER cargo receptor SURF4 as a key determinant in the secretion of PCSK9, a protein that regulates human cholesterol levels and cardiovascular disease risk.

Promoting a Warburg-like shift in astrocytic metabolism through reduced mitochondrial electron transport accommodates the energetic burden caused by brain trauma without overwhelming cellular respiration and redox to salvage dopaminergic neurons.

Enzyme tethering of promiscuous biotinylators to the cell surface allows for more rapid and efficient comparative surface proteomic analysis of cells and extracellular vesicles.

Ribosome profiling and loss-of-function during human ESC pancreatic differentiation reveal abundant lncRNA translation and an essential role for translated LINC00261 in beta cell differentiation, likely through a trans-regulatory, microprotein-independent mechanism.

Hedgehog leads to Smoothened accumulation by favoring its recycling and high Hedgehog levels promote a basolateral enrichment of Smoothened via its phosphorylation by the protein kinase Fused.

Circulation of molecules from the brain can serve as a rapid mode of communication from the brain to the liver.

Macaque monkeys temporally compress past experiences and use a forward-replay mechanism during judgment of temporal-order between episodes.

A 3D model captures the growth and expansion dynamics of bacterial colonies, revealing distinct effects of surface tension, mechanical forces, and nutrients on the speed of radial and vertical expansion.

Pulse electron paramagnetic resonance on intact Escherichia coli reveals a substrate-induced structural transition in BtuB, the vitamin B₁₂ transporter, which is not seen in reconstituted membranes and indicates a mechanism of transport.