585 results found
    1. Neuroscience

    Canonical goal-selective representations are absent from prefrontal cortex in a spatial working memory task requiring behavioral flexibility

    Claudia Böhm, Albert K Lee
    Representation of goals in the forms previously reported in the PFC is not required for performance of a novel spatial working memory task where goal information must be used flexibly.
    1. Neuroscience

    Small molecule cognitive enhancer reverses age-related memory decline in mice

    Karen Krukowski et al.
    Inhibition of the integrated stress response restores neuronal and immune dysfunction and alleviates memory deficits in aged mice.
    1. Cell Biology
    2. Physics of Living Systems

    Metabolic constraints drive self-organization of specialized cell groups

    Sriram Varahan et al.
    In a developing yeast colony, cells go from homogeneous states to spatially organized, specialized metabolic states, and the new metabolic states depend on resources produced by the original state.
    1. Neuroscience

    Cortical astrocytes independently regulate sleep depth and duration via separate GPCR pathways

    Trisha V Vaidyanathan et al.
    Cortical astrocytes play key roles in NREM sleep by regulating sleep depth and duration through separate GPCR pathways, and differentially control neuronal slow-wave activity in local and remote cortical circuits.
    1. Cell Biology
    2. Neuroscience

    Antagonistic roles for Ataxin-2 structured and disordered domains in RNP condensation

    Amanjot Singh et al.
    Ataxin-2 interacts with neuronal mRNA in RNP granules.
    1. Developmental Biology

    An atlas of neural crest lineages along the posterior developing zebrafish at single-cell resolution

    Aubrey GA Howard IV et al.
    Single-cell dissection of recent neural crest derivatives in the vertebrate zebrafish reveals diverse transcriptomic signatures among differentiating posterior cell types during the embryonic to larval stage transition.
    1. Developmental Biology
    2. Neuroscience

    Comparison of induced neurons reveals slower structural and functional maturation in humans than in apes

    Maria Schörnig et al.
    Neurons mature slower in humans than in other non-human primates.
    1. Neuroscience

    Paranoia as a deficit in non-social belief updating

    Erin J Reed et al.
    Paranoia is underwritten by variation in prior beliefs about how the world will change and how to learn from those changes.
    1. Evolutionary Biology
    2. Neuroscience

    A novel acidification mechanism for greatly enhanced oxygen supply to the fish retina

    Christian Damsgaard et al.
    A novel mode of oxygen delivery facilitated the adaptive evolution of vision in teleost fishes.
    1. Evolutionary Biology

    Retinal oxygen supply shaped the functional evolution of the vertebrate eye

    Christian Damsgaard et al.
    Multiple respiratory and vascular mechanisms have recurrently evolved across the vertebrates to alleviate the oxygen diffusion limitations inherent to the morphology of the retina.

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