By moving between DNA segments like a child swinging on monkey bars, poly(ADP-ribose) polymerase 1 explores possible DNA damage sites more effectively.
Synthetic single domain antibody libraries and a binder selection cascade encompassing ribosome and phage display enable the selection of conformation-specific binders against previously intractable membrane proteins within three weeks.
In a 3D culture model of breast epithelium, application of a short-timescale compression to single malignant cells promotes the long-timescale development of polarized, growth-arrested structures.
Simultaneous phosphorylation of multiple substrate motifs drives switch-like target recognition and monoubiquitylation by an E3 ligase during metazoan development.
The impact of changing gene expression noise on fitness reveals beneficial or deleterious effects in a stable environment depending how close the average expression level is to the fitness optimum.
Twinfilin functions as a pro-capping ligand of capping protein, dynamically competing with inhibitory ligands of capping proteinto control cellular actin assembly.
