11 results found
    1. Evolutionary Biology

    Ongoing resolution of duplicate gene functions shapes the diversification of a metabolic network

    Meihua Christina Kuang et al.
    Recent functional changes in ancient duplicate genes led to the evolution of divergent regulatory and metabolic strategies by the GALactose gene networks of two yeast species.
    1. Ecology
    2. Genetics and Genomics

    The Natural History of Model Organisms: The fascinating and secret wild life of the budding yeast S. cerevisiae

    Gianni Liti
    The yeast Saccharomyces cerevisiae has informed our understanding of molecular biology and genetics for decades, and learning more about its natural history could fuel a new era of functional and evolutionary studies of this classic model organism.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Proteome-wide signatures of function in highly diverged intrinsically disordered regions

    Taraneh Zarin et al.
    Widespread, rapidly evolving disordered regions contain molecular features that are preserved over evolution and are associated with specific biological functions.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    The dynamic three-dimensional organization of the diploid yeast genome

    Seungsoo Kim et al.
    Yeast homologous chromosomes exhibit condition-specific mitotic pairing at both global and local scales.
    1. Chromosomes and Gene Expression

    Msn2/4 regulate expression of glycolytic enzymes and control transition from quiescence to growth

    Zheng Kuang et al.
    General stress response factors Msn2 and Msn4 activate glycolytic genes and promote acetyl-CoA accumulation to stimulate growth and proliferation of yeast cells under a nutrient-limiting condition, suggesting the unexpected interrelationship between carbohydrate metabolism and stress response.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Synteny-based analyses indicate that sequence divergence is not the main source of orphan genes

    Nikolaos Vakirlis et al.
    Homology information implicit in regions of conserved synteny allows quantification of gene origination by complete sequence divergence, revealing a larger-than-expected role for other mechanisms of origin, including de novo origination.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural and biochemical analyses of the DEAD-box ATPase Sub2 in association with THO or Yra1

    Yi Ren et al.
    Biochemical and structural analyses of a universal mRNP remodeling pathway suggest an ATPase-powered targeted deposition of export factors onto mRNP.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Metagenomic chromosome conformation capture (meta3C) unveils the diversity of chromosome organization in microorganisms

    Martial Marbouty et al.
    A technique called meta3C provides an elegant and integrated approach to metagenomic analysis by allowing the de novo assembly, scaffolding and 3D characterization of unknown genomes from a complex mix of species
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Evolutionary principles of modular gene regulation in yeasts

    Dawn A Thompson et al.
    The divergence of gene regulation during evolution in yeast traces phylogenetic distance with prominent changes being associated with changes in lifestyle and a whole genome duplication event.
    1. Chromosomes and Gene Expression

    Kinetochore inactivation by expression of a repressive mRNA

    Jingxun Chen et al.
    Rather than being a protein coding unit, an mRNA molecule can serve a purely regulatory function to inhibit protein synthesis of its corresponding gene.

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