7 results found
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Altered bone growth dynamics prefigure craniosynostosis in a zebrafish model of Saethre-Chotzen syndrome

    Camilla S Teng et al.
    Sequential live imaging of abnormal skull bone fusion in zebrafish reveals a deeply conserved role of two transcription factors, Twist1 and Tcf12, in regulating stem cell activity during growth of the skull.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structures reveal opening of the store-operated calcium channel Orai

    Xiaowei Hou et al.
    The structure of the calcium channel Orai in an open conformation reveals a dilated pore and gives insight into mechanisms of ion permeation and calcium selectivity.
    1. Developmental Biology
    2. Evolutionary Biology

    Resolving homology in the face of shifting germ layer origins: Lessons from a major skull vault boundary

    Camilla S Teng et al.
    Homology of vertebrate skull structures should be based on evolutionary continuity and an appreciation of germ layer origins and inductive signaling in the embryonic head.
    1. Developmental Biology

    Quantification of gene expression patterns to reveal the origins of abnormal morphogenesis

    Neus Martínez-Abadías et al.
    Quantitative analyses associating the morphology of developing organs with dynamic gene expression patterns can reveal biological phenomena that cause malformations and malfunction but remain elusive to traditional qualitative assessments.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Mitochondrial Bol1 and Bol3 function as assembly factors for specific iron-sulfur proteins

    Marta A Uzarska et al.
    Cell biological, biochemical and structural studies reveal the mechanistic roles of two new mitochondrial iron-sulfur protein assembly factors, explaining the patho-biochemical defects of affected patients.
    1. Stem Cells and Regenerative Medicine

    Transcriptional landscape of myogenesis from human pluripotent stem cells reveals a key role of TWIST1 in maintenance of skeletal muscle progenitors

    In Young Choi et al.
    Using multiple genetic reporter system in human pluripotent stem cells, a transcriptional database for human early myogenesis has been established.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Origins of the 2009 H1N1 influenza pandemic in swine in Mexico

    Ignacio Mena et al.
    Genome sequence data from 58 Mexican swine influenza A viruses resolves the spatial origin of the virus that originated the influenza pandemic of 2009.

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