The transcription coactivators SAGA and TFIID have redundant function at a subset of yeast genes while SAGA also contributes to transcription of all genes through regulation of chromatin modifications.

Volatile compounds from microbes and food alter epigenetic states by inhibiting histone deacetylases and alter gene expression, slow degeneration in Huntington’s model flies, and slow proliferation of a neuroblastoma cell line.

In small cell lung cancer, the transition from a neuroendocrine state to a more neuronal state endows these cancer cells with increased migration and metastatic potential.

Recordings from serotonin-producing neurons in the brain reveal that these neurons are highly activated by sudden changes in previously familiar environments, potentially explaining why serotonin is important for learning to adapt to such changes.

Functional genomics reveal complex genome regulation during the coenocytic development of the ichthyosporean Creolimax fragrantissima, a protist closely related to animals.

Contrasting climatic dependencies of macrofauna and microorganisms generate similar whole-community decomposition rates across a precipitation gradient, plausibly resolving the longstanding puzzle of why arid-land litter decomposition is decoupled from precipitation.

An unbiased biochemical screen reveals a direct link between gene regulation and actin cytoskeleton remodeling.

The SAGA complex binds non-chromosomal DNA circles and prevents their spreading by attaching them to nuclear pores, thereby leading to the concomitant accumulation of DNA circles and pores in ageing yeast mother cells.

An atomic model of the 3744-residue Tra1 protein reveals multiple transcription activator binding sites, its integration within the SAGA chromatin coactivator complex, and a striking similarity to DNA-repair factor DNA-PKcs.

Identification of two classes of mouse vomeronasal receptors for female pheromone cues suggests distinct gating mechanisms in pheromone-triggered reproductive behaviors.