Browse the search results

Comprehensive genome-wide associations studies in flies identify new genes and pathways critical for heart development and function and display relevant overlap with human genetic risks related to cardiac performance.

Apicomplexan parasites secrete proteins to manipulate their hosts from sub-apical openings in their cell pellicle that are distinct from the apical complex from where invasion factors are secreted.

Unconventional secretion of a plasma membrane purine transporter via Golgi-bypass is established at an early ER-associated secretory compartment revealing that specific cargoes define alternative trafficking routes.

A molecular genetics study reveals an accessory olfactory-to-hypothalamic circuit in mice that optimizes defensive behaviors according to the imminence of predator threats.

Inducing presomitic mesoderm (PSM)-fated ES cells clarified that Ripply2 directly interacts with Tbx6 and degrades Tbx6 in proteasome-ubiquitin pathway by recruiting the 26S proteasome, which is a PSM-specific event to define the segment border during mouse somitogenesis.

The dietary vitamin riboflavin provides the chemical backbone to generate essential substrates that support liver glucose metabolism during low-nutrient conditions.

Autophagic cargo receptors recruit the E3-like enzyme for Atg8 lipid conjugation to the cargo and thereby promote local formation of Atg8-positive autophagosomal membranes.

Cells exhibit a localized ATR-dependent DNA damage response to a site-specific stalled replication fork that is distinct from that observed after global replication stress.

The mirror-symmetric structure of the Caenorhabditis elegans gonad is established through the Wnt-independent function of a Frizzled protein and three Wnt proteins with distinct roles.

In a mouse model of DYT25 dystonia with disruption of striatal neurotransmission by Gnal mutation, the cerebello-thalamic excitability is increased following symptom expression and θ-burst cerebellar stimulations during cholinergic-induced dystonia depress the cerebello-thalamic transmission and reduce the motor symptom severity.