753 results found
    1. Epidemiology and Global Health

    Alcohol consumption in the general population is associated with structural changes in multiple organ systems

    Evangelos Evangelou et al.
    The results imply that there is not a safe threshold below which there are no toxic effects of alcohol.
    1. Neuroscience

    The organizational principles of de-differentiated topographic maps in somatosensory cortex

    Peng Liu et al.
    SI topographic finger maps of older adults show signs of cortical aging but do not show classical hallmarks of cortical de-differentiation.
    1. Epidemiology and Global Health

    Asymptomatic Bordetella pertussis infections in a longitudinal cohort of young African infants and their mothers

    Christopher J Gill et al.
    Longitudinal qPCR-based pertussis surveillance of a low-resource African cohort reveals frequent asymptomatic pertussis infections in both young infants and mothers and suggests possible early warning signals for epidemic outbreaks.
    1. Cell Biology
    2. Neuroscience

    Short and long sleeping mutants reveal links between sleep and macroautophagy

    Joseph L Bedont et al.
    Unbiased and targeted genetic approaches reveal a link between sleep and autophagy that could be relevant for sleep function, and for understanding pathological consequences of chronic sleep loss.
    1. Neuroscience

    Autism-associated SHANK3 missense point mutations impact conformational fluctuations and protein turnover at synapses

    Michael Bucher et al.
    Autism-associated SHANK3 missense mutations result in differential protein folding, stability, and intramolecular dynamics affecting its turnover at the synapse.
    1. Microbiology and Infectious Disease

    4-Hydroxy-2-nonenal antimicrobial toxicity is neutralized by an intracellular pathogen

    Hannah Tabakh et al.
    The aldehyde 4-hydroxy-2-nonenal is a novel component of the host antimicrobial reactive oxygen burst, and the bacterium Listeria monocytogenes encodes genes specifically for its detoxification.
    1. Cell Biology

    Starvation-induced regulation of carbohydrate transport at the blood–brain barrier is TGF-β-signaling dependent

    Helen Hertenstein et al.
    Detailed analysis of transporter expression and glucose uptake rates shows that carbohydrate import at the blood–brain barrier is adapted via TGF-βsignaling-dependent transcriptional regulation of carbohydrate transporters to protect the brain form effects of nutrient shortage.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Permeant fluorescent probes visualize the activation of SARM1 and uncover an anti-neurodegenerative drug candidate

    Wan Hua Li et al.
    The first-in-class cell-permeant fluorescent probe provides direct and visual evidence of SARM1 activation in axonal degeneration and identified the first covalent, allosteric inhibitor of SARM1 acting on the NAD-binding pocket in the ARM domain.
    1. Neuroscience

    Adapting non-invasive human recordings along multiple task-axes shows unfolding of spontaneous and over-trained choice

    Yu Takagi et al.
    Adaptation along multiple task-axes reveals choice traces at millisecond resolution in non-invasive recordings from human premotor cortex and provides evidence that theories of top-down control hold even after extensive experience.
    1. Developmental Biology
    2. Neuroscience

    Qki regulates myelinogenesis through Srebp2-dependent cholesterol biosynthesis

    Xin Zhou et al.
    Qki-Srebp2–mediated cholesterol biosynthesis is indispensable for myelinogenesis during early brain development.

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