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    1. Developmental Biology
    2. Plant Biology

    Temporal integration of auxin information for the regulation of patterning

    Carlos S Galvan-Ampudia et al.
    Rhythmic centrifugal waves of auxin traveling through the tissue provides high definition positional information to cells that is not only spatial but also temporal.
    1. Cell Biology
    2. Plant Biology

    A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress

    Madlen Stephani et al.
    C53 bridges selective autophagy with ribosome-associated quality control at the endoplasmic reticulum.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Caenorhabditis elegans methionine/S-adenosylmethionine cycle activity is sensed and adjusted by a nuclear hormone receptor

    Gabrielle E Giese et al.
    Metabolic activity of the methionine/S-adenosylmethionine cycle is sensed and transcriptionally regulated by a nuclear hormone receptor in Caenorhabditis elegans in order to maintain metabolic homeostasis in a tightly controlled regime.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A putative ATPase mediates RNA transcription and capping in a dsRNA virus

    Xuekui Yu et al.
    Atomic structures suggest a novel mechanism for the regulation of mRNA transcription and capping in dsRNA viruses.
    1. Computational and Systems Biology
    2. Stem Cells and Regenerative Medicine

    Self-assembling manifolds in single-cell RNA sequencing data

    Alexander J Tarashansky et al.
    An iterative self-assembling algorithm identifies the intrinsic structures in single-cell transcriptomic data and helps to discover new cell populations that are undetectable by existing methods.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural insights into the molecular mechanism of the m6A writer complex

    Paweł Śledź, Martin Jinek
    The structure of the catalytic core of the N6-methyladenosine RNA methyltransferase complex METTL3-METTL14 reveals that METTL3 is the catalytic subunit, while METTL14 plays non-catalytic roles in substrate recognition and in maintaining complex integrity.
    1. Biochemistry and Chemical Biology

    The dynamic conformational landscape of the protein methyltransferase SETD8

    Shi Chen et al.
    Integrated experimental-computational approaches were implemented to reveal the dynamic conformational landscape of a biologically relevant protein methyltransferase SETD8 for functional annotation.
    1. Plant Biology

    Convergent recruitment of TALE homeodomain life cycle regulators to direct sporophyte development in land plants and brown algae

    Alok Arun et al.
    TALE homeodomain transcription factors have been independently recruited to regulate gametophyte to sporophyte transitions in two complex multicellular eukaryotic supergroups, land plants in Archaeplastida and brown algae in Chromalveolata.
    1. Neuroscience

    The cerebellum is involved in processing of predictions and prediction errors in a fear conditioning paradigm

    Thomas Michael Ernst et al.
    Pronounced cerebellar activation during unexpected omission of a potentially harmful event suggests that the cerebellum has to be added to the neural network processing prediction errors underlying emotional associative learning.
    1. Cell Biology

    Electron cryo-tomography provides insight into procentriole architecture and assembly mechanism

    Sam Li et al.
    A detailed description of the structure of procentriole MT triplet by cryoET, along with its associated non-tubulin proteins and its assembly intermediates, reveals possible molecular mechanism for the procentriole assembly.