Metabolic activity of the methionine/S-adenosylmethionine cycle is sensed and transcriptionally regulated by a nuclear hormone receptor in Caenorhabditis elegans in order to maintain metabolic homeostasis in a tightly controlled regime.
The structure of the catalytic core of the N6-methyladenosine RNA methyltransferase complex METTL3-METTL14 reveals that METTL3 is the catalytic subunit, while METTL14 plays non-catalytic roles in substrate recognition and in maintaining complex integrity.
TALE homeodomain transcription factors have been independently recruited to regulate gametophyte to sporophyte transitions in two complex multicellular eukaryotic supergroups, land plants in Archaeplastida and brown algae in Chromalveolata.
Pronounced cerebellar activation during unexpected omission of a potentially harmful event suggests that the cerebellum has to be added to the neural network processing prediction errors underlying emotional associative learning.
A detailed description of the structure of procentriole MT triplet by cryoET, along with its associated non-tubulin proteins and its assembly intermediates, reveals possible molecular mechanism for the procentriole assembly.