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Page 4 of 1,052
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Neuroprotective effects of TRPA1 channels in the cerebral endothelium following ischemic stroke

    Paulo Wagner Pires, Scott Earley
    Acute hypoxia activates TRPA1 channels in cerebral artery endothelial cells to activate an early adaptive response to reduce tissue ischemic damage through vasodilation.
    1. Cell Biology

    Thrombospondin expression in myofibers stabilizes muscle membranes

    Davy Vanhoutte et al.
    Thrombospondin proteins regulate vesicular trafficking of integrins and other membrane attachment complex proteins to the plasma membrane of skeletal muscle, which provides greater stability and resistance to muscular dystrophy.
    1. Plant Biology

    Phenotypic landscape inference reveals multiple evolutionary paths to C4 photosynthesis

    Ben P Williams et al.
    Computational modelling indicates that C4 photosynthesis in distantly related plant species arose through a number of independent evolutionary paths.
    1. Neuroscience

    Learning speed and detection sensitivity controlled by distinct cortico-fugal neurons in visual cortex

    Sarah Ruediger, Massimo Scanziani
    Neural pathways from mammalian visual cortex to ancestral brain structures control learning speed and performance of a simple detection task.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Synergy between Wsp1 and Dip1 may initiate assembly of endocytic actin networks

    Connor J Balzer et al.
    An activator of branching nucleation by Arp2/3 complex directly synergizes with an activator of linear filament nucleation to initiate assembly of actin networks that drive endocytosis.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Disease-related mutations in PI3Kγ disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors

    Manoj K Rathinaswamy et al.
    The c-terminus of PI3K plays a key role in regulating kinase activity, with c-terminal disease-linked mutations leading to either activation or inhibition, which reveal a path to specific inhibitors.
    1. Cell Biology
    2. Developmental Biology

    The ribosomal RNA m5C methyltransferase NSUN-1 modulates healthspan and oogenesis in Caenorhabditis elegans

    Clemens Heissenberger et al.
    In nematode worms, NSUN-1 methylates ribosomal RNA and influences phenotypes related to aging, stress resistance, germ line development, and cuticle integrity by regulating translation of specific mRNAs.
    1. Structural Biology and Molecular Biophysics

    Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling

    Naotaka Tsutsumi et al.
    Cryo-EM structure of monomeric human Frizzled5 was determined with a universal fiducial antibody at 3.7 Å overall resolution, which supports a simple Fzd/LRP6 heterodimerization mechanism of canonical Wnt/β-catenin signaling.
    1. Developmental Biology
    2. Neuroscience

    Regulation of nerve growth and patterning by cell surface protein disulphide isomerase

    Geoffrey MW Cook et al.
    The nerve growth-repellent activity that generates spinal nerve repeat-patterning in birds and mammals is identified at the molecular level, and a similar system is revealed in adult brain grey matter.
    1. Cell Biology
    2. Developmental Biology

    Notch signaling restricts FGF pathway activation in parapineal cells to promote their collective migration

    Lu Wei et al.
    Notch signaling controls the collective migration of parapineal cells through its capacity to restrict FGF pathway activation to a few leading cells.