221 results found
    1. Genetics and Genomics
    2. Stem Cells and Regenerative Medicine

    Cell-type diversity and regionalized gene expression in the planarian intestine

    David J Forsthoefel et al.
    Application of laser-capture microdissection to planarian intestinal tissue provides a new tool for analysis of tissue-specific gene expression in flatworms, and a new resource to advance investigations of gastrointestinal regeneration.
    1. Immunology and Inflammation

    High-dimensional analysis of intestinal immune cells during helminth infection

    Laura Ferrer-Font et al.
    A systematic optimization of intestinal digestion protocols allows for the isolation and high-dimensional flow cytometric analysis of intestinal immune cells during murine helminth infection.
    1. Developmental Biology

    The Apelin receptor enhances Nodal/TGFβ signaling to ensure proper cardiac development

    Ashish R Deshwar et al.
    The Apelin receptor acts as a rheostat to ensure that the proper levels of Nodal signaling are achieved for proper cell fate specification at the onset of gastrulation, in particular for cardiac progenitor development.
    1. Neuroscience

    Calcium imaging with genetically encoded indicators in behaving primates

    Eyal Seidemann et al.
    The link between the activity of large populations of cortical neurons and single neuron responses is examined in primates using a new optical-genetic method.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Novel RNA and DNA strand exchange activity of the PALB2 DNA binding domain and its critical role for DNA repair in cells

    Jaigeeth Deveryshetty et al.
    Biochemical studies revealed novel property of human tumor suppressor PALB2, which significantly contribute into DNA repair in cells and can be targeted for the development of novel anticancer treatment.
    1. Developmental Biology

    The hormonal peptide Elabela guides angioblasts to the midline during vasculogenesis

    Christian SM Helker et al.
    Elabela-Apelin receptor signaling is a novel pathway that regulates angioblast migration, instead of the proposed migration regulation through Vascular endothelial growth factor.
    1. Structural Biology and Molecular Biophysics
    2. Developmental Biology

    Quantitative imaging reveals real-time Pou5f3–Nanog complexes driving dorsoventral mesendoderm patterning in zebrafish

    Mireia Perez-Camps et al.
    Different combinations of the transcription factors Pou5f3, Nanog and Sox32 form complexes to drive dorsoventral mesendoderm patterning in zebrafish.
    1. Developmental Biology
    2. Neuroscience

    DCC regulates astroglial development essential for telencephalic morphogenesis and corpus callosum formation

    Laura Morcom et al.
    Axon guidance molecules DCC and NTN1 regulate astroglial-mediated interhemispheric remodelling required for corpus callosum formation in humans and mice.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    The deubiquitylase Ubp15 couples transcription to mRNA export

    Fanny Eyboulet et al.
    Ubp15 regulates the ubiquitylation of the export adaptor Mex67.

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