32 results found
    1. Microbiology and Infectious Disease

    Programmed genome editing of the omega-1 ribonuclease of the blood fluke, Schistosoma mansoni

    Wannaporn Ittiprasert et al.
    Gene knock-out of the omega-1 ribonuclease of Schistosoma mansoni eggs resulted in immunologically impaired phenotype, showcasing the novel application of CRISPR/Cas9 genome editing and utility for functional genomics in schistosomes.
    1. Microbiology and Infectious Disease
    2. Stem Cells and Regenerative Medicine

    Stem cell heterogeneity drives the parasitic life cycle of Schistosoma mansoni

    Bo Wang et al.
    Distinct stem cell populations drive larval, somatic, and germline development of the human parasitic flatworm, Schistosoma mansoni.
    1. Developmental Biology
    2. Microbiology and Infectious Disease

    Flatworm-specific transcriptional regulators promote the specification of tegumental progenitors in Schistosoma mansoni

    George R Wendt et al.
    The specification of tegumental progenitor cells in Schistosoma mansoni relies on a pair of flatworm-specific transcription factors that are related to genes regulating epidermal specification in free-living flatworms.
    1. Stem Cells and Regenerative Medicine
    2. Microbiology and Infectious Disease

    Functional genomic characterization of neoblast-like stem cells in larval Schistosoma mansoni

    Bo Wang et al.
    Cells that give rise to the infectious form of parasitic flatworms called schistosomes show similar patterns of gene expression to stem cells in free-living flatworms.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Evolution of gene dosage on the Z-chromosome of schistosome parasites

    Marion A L Picard et al.
    An analysis of gene dosage at the DNA, RNA and protein level yields new insights into the early stages of Z-chromosome dosage compensation in schistosome parasites.
    1. Microbiology and Infectious Disease

    Coordination of humoral immune factors dictates compatibility between Schistosoma mansoni and Biomphalaria glabrata

    Hongyu Li et al.
    A coordinated humoral immune response that includes recognition, effector and cytotoxic factors engages the cell-mediated immune response to defend a snail against infection by schistosome parasites.
    1. Ecology
    2. Epidemiology and Global Health

    Antagonism between parasites within snail hosts impacts the transmission of human schistosomiasis

    Martina R Laidemitt et al.
    Interactions among parasites in snails create cascading effects on their transmission and highlight that biodiversity has complex, context-dependent and important effects on human schistosomiasis transmission dynamics.
    1. Stem Cells and Regenerative Medicine
    2. Microbiology and Infectious Disease

    Stem cell progeny contribute to the schistosome host-parasite interface

    James J Collins III et al.
    Stem cells are found to continually rejuvenate the epidermis of the human parasite Schistosoma mansoni.
    1. Computational and Systems Biology
    2. Stem Cells and Regenerative Medicine

    Self-assembling manifolds in single-cell RNA sequencing data

    Alexander J Tarashansky et al.
    An iterative self-assembling algorithm identifies the intrinsic structures in single-cell transcriptomic data and helps to discover new cell populations that are undetectable by existing methods.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Clusters of polymorphic transmembrane genes control resistance to schistosomes in snail vectors

    Jacob A Tennessen et al.
    A region of the Biomphalaria genome, containing highly divergent haplotypes with different combinations of transmembrane genes, strongly impacts whether these snails can transmit parasitic schistosomes.

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