David GT Barrett, Sophie Denève, Christian K Machens
Spiking networks compensate the loss of neurons instantaneously, when restoration of excitatory/inhibitory balance becomes equivalent to restoration of functionality.
Samuel Pattillo Smith, Gregory Darnell ... Lorin Crawford
Computational analysis reveals that additive summary statistics from genome-wide association studies can provide evidence of non-additive heritability in complex traits.
Temporally delayed linear modelling provides a domain-general linear framework for sequence detection and statistical testing, and is able to detect replays in both human neuroimaging and animal electrophysiology.
Guido I Guberman, Sonja Stojanovski ... Maxime Descoteaux
In paediatric concussions, there are a multiplicity of ways that brain damage gives rise to symptoms, most of which are missed by conventional statistical approaches and study designs.
Hierarchical modeling of internalizing symptoms and task performance reveals that difficulty adapting probabilistic learning to second-order uncertainty is common to anxiety and depression and holds across rewarding and punishing outcomes.
Benjamin W Okaty, Nikita Sturrock ... Susan M Dymecki
Dorsal raphe Pet1 neurons are molecularly heterogeneous, comprising as many as fourteen distinct subtypes that show biased cell body distributions across dorsal raphe subdomains.
Structural biology studies reveal the importance of protein dynamics on understanding molecular mechanisms underlying allosteric modulation of G protein-coupled receptors (GPCR) that offer insights into future GPCR research and drug discovery.